No evidence for the presence of neuronal surface autoantibodies in plasma of patients with schizophrenia

The GROUP investigators

doi:10.1016/j.euroneuro.2015.09.017

No evidence for the presence of neuronal surface autoantibodies in plasma of patients with schizophrenia

The GROUP investigators

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The immune system has been implicated in the etiology of schizophrenia. Autoimmunity by antibodies against neuronal cell surface antigens has been proposed as one of the pathological mechanisms. We examined plasma samples of 104 patients diagnosed with schizophrenia for the presence of autoantibodies against neuronal cell surface antigens using cultured hippocampal neurons and transfected HeLa cells. None of the samples tested positive for the presence of these autoantibodies. Based on our results it seems unlikely that autoantibodies against neuronal cell surface antigens play a role in the pathogenesis of schizophrenia, although further studies using cerebrospinal fluid are needed.

Original language	English
Pages (from-to)	2326-2332
Number of pages	7
Journal	European Neuropsychopharmacology
Volume	25
Issue number	12
DOIs	https://doi.org/10.1016/j.euroneuro.2015.09.017
State	Published - 1 Dec 2015
Externally published	Yes

Keywords

Antibodies
Autoimmune
Encephalitis
Immunology
Psychosis
Schizophrenia

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10.1016/j.euroneuro.2015.09.017

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title = "No evidence for the presence of neuronal surface autoantibodies in plasma of patients with schizophrenia",

abstract = "The immune system has been implicated in the etiology of schizophrenia. Autoimmunity by antibodies against neuronal cell surface antigens has been proposed as one of the pathological mechanisms. We examined plasma samples of 104 patients diagnosed with schizophrenia for the presence of autoantibodies against neuronal cell surface antigens using cultured hippocampal neurons and transfected HeLa cells. None of the samples tested positive for the presence of these autoantibodies. Based on our results it seems unlikely that autoantibodies against neuronal cell surface antigens play a role in the pathogenesis of schizophrenia, although further studies using cerebrospinal fluid are needed.",

keywords = "Antibodies, Autoimmune, Encephalitis, Immunology, Psychosis, Schizophrenia",

author = "\{The GROUP investigators\} and \{van Mierlo\}, \{Hans C.\} and \{van Coevorden-Hameete\}, \{Marleen H.\} and Munting, \{Leon P.\} and \{de Graaff\}, Esther and \{de Witte\}, Lot and Richard Bruggeman and Wiepke Cahn and \{de Haan\}, Lieuwe and Kahn, \{Ren{\'e} S.\} and Meijer, \{Carin J.\} and Inez Myin-Germeys and \{van Os\}, Jim and Durk Wiersma",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier B.V. and ECNP.",

year = "2015",

month = dec,

day = "1",

doi = "10.1016/j.euroneuro.2015.09.017",

language = "English",

volume = "25",

pages = "2326--2332",

journal = "European Neuropsychopharmacology",

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T1 - No evidence for the presence of neuronal surface autoantibodies in plasma of patients with schizophrenia

AU - The GROUP investigators

AU - van Mierlo, Hans C.

AU - van Coevorden-Hameete, Marleen H.

AU - Munting, Leon P.

AU - de Graaff, Esther

AU - de Witte, Lot

AU - Bruggeman, Richard

AU - Cahn, Wiepke

AU - de Haan, Lieuwe

AU - Kahn, René S.

AU - Meijer, Carin J.

AU - Myin-Germeys, Inez

AU - van Os, Jim

AU - Wiersma, Durk

PY - 2015/12/1

Y1 - 2015/12/1

N2 - The immune system has been implicated in the etiology of schizophrenia. Autoimmunity by antibodies against neuronal cell surface antigens has been proposed as one of the pathological mechanisms. We examined plasma samples of 104 patients diagnosed with schizophrenia for the presence of autoantibodies against neuronal cell surface antigens using cultured hippocampal neurons and transfected HeLa cells. None of the samples tested positive for the presence of these autoantibodies. Based on our results it seems unlikely that autoantibodies against neuronal cell surface antigens play a role in the pathogenesis of schizophrenia, although further studies using cerebrospinal fluid are needed.

AB - The immune system has been implicated in the etiology of schizophrenia. Autoimmunity by antibodies against neuronal cell surface antigens has been proposed as one of the pathological mechanisms. We examined plasma samples of 104 patients diagnosed with schizophrenia for the presence of autoantibodies against neuronal cell surface antigens using cultured hippocampal neurons and transfected HeLa cells. None of the samples tested positive for the presence of these autoantibodies. Based on our results it seems unlikely that autoantibodies against neuronal cell surface antigens play a role in the pathogenesis of schizophrenia, although further studies using cerebrospinal fluid are needed.

KW - Antibodies

KW - Autoimmune

KW - Encephalitis

KW - Immunology

KW - Psychosis

KW - Schizophrenia

UR - https://www.scopus.com/pages/publications/84951264106

U2 - 10.1016/j.euroneuro.2015.09.017

DO - 10.1016/j.euroneuro.2015.09.017

M3 - Article

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AN - SCOPUS:84951264106

SN - 0924-977X

VL - 25

SP - 2326

EP - 2332

JO - European Neuropsychopharmacology

JF - European Neuropsychopharmacology

IS - 12

ER -

No evidence for the presence of neuronal surface autoantibodies in plasma of patients with schizophrenia

Abstract

Keywords

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