@article{a4b60492d8f4450a9132d87dc0589dd5,
title = "No association of presenilin-1 intronic polymorphism and Alzheimer's disease in Australia",
abstract = "We screened 703 Australian subjects for an intronic polymorphism in the presenilin-1 (PS-1) gene. PS-1 intronic allele 1 homozygosity was not associated with individuals with early- or late-onset sporadic Alzheimer's disease (EOAD or LOAD). Carriers for the PS-1 intronic allele 1 were also not associated with significantly increased risk for AD regardless of gender. Our results for the Australian population are consistent with those of recent reports for other populations and do no support the conclusion that the PS-1 intronic polymorphism is associated with AD.",
keywords = "Alzheimer's disease, Chromosome, Genetics, Intronic polymorphism, Presenilin-1",
author = "K. Taddei and D. Yang and C. Fisher and R. Clarnette and J. Hallmayer and R. Barnetson and R. Maller and Brooks, {W. S.} and S. Whyte and Nicholson, {G. A.} and Masters, {C. L.} and Broe, {G. A.} and Gandy, {S. E.} and Martins, {R. N.}",
note = "Funding Information: The excellent technical assistance of Athena Paton and Georgia Martins is most appreciated for the collection and processing of blood samples. The authors thank Jenny Millar for typing this manuscript. Special thanks go to all Alzheimer's disease patients, normal aged controls and their families for participation in this study. Supported by grants from Sir James McCusker, the Department of Veteran Affairs (R.N.M.), the USPHS (A.G. 11508 to S.G.) and the C.S. Starr Foundation (S.G). ",
year = "1998",
month = apr,
day = "10",
doi = "10.1016/S0304-3940(98)00248-1",
language = "English",
volume = "246",
pages = "178--180",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "3",
}