No association between y chromosomal haplogroups and severe acne in the Han Chinese population

Mei Hua Guo; Wen Juan Wu; Long Fan; Min Sheng Peng; Jian Kang Yang; Wen Zhang; Fei Hao; Hong Fu Xie; Lei Hong Xiang; Min Zheng; Yan Ni Guo; Qing Hua Song; Cai Xia Tu; Hua Zhong; Wen Ge Fan; Yue Jun Shi; Ping Cao; Lian Yuan Feng; Meng Na; Qin Pang; Xiao Yan Yang; Cheng Yang; Xi Zou; Li He; Ya Ping Zhang

doi:10.1038/jhg.2014.53

No association between y chromosomal haplogroups and severe acne in the Han Chinese population

Mei Hua Guo
, Wen Juan Wu
, Long Fan
, Min Sheng Peng
, Jian Kang Yang
, Wen Zhang
, Fei Hao
, Hong Fu Xie
, Lei Hong Xiang
, Min Zheng
, Yan Ni Guo
, Qing Hua Song
, Cai Xia Tu
, Hua Zhong
, Wen Ge Fan
, Yue Jun Shi
, Ping Cao
, Lian Yuan Feng
, Meng Na
, Qin Pang

Xiao Yan Yang, Cheng Yang, Xi Zou, Li He, Ya Ping Zhang

Research output: Contribution to journal › Article › peer-review

Abstract

Severe acne presents sexual dimorphism in its incidence in Chinese population. It is more prevalent in males. To assess the possible Y chromosomal contribution to severe acne risk in Han Chinese males, we analyzed 2041 Y chromosomal SNPs (Y-SNPs) in 725 severe acne cases and 651 controls retrieved from our recent genome-wide association study data. After data filtering, we assigned 585 cases and 494 controls into 12 Y chromosomal haplogroups based on 307 high-confidence Y-SNPs. No statistically significant difference in the distribution of Y chromosomal haplogroup frequencies was observed between the case and control groups. Our results showed a lack of association between the incidence of severe acne and the different Y chromosomal haplogroup in the Han Chinese population.

Original language	English
Pages (from-to)	475-476
Number of pages	2
Journal	Journal of Human Genetics
Volume	59
Issue number	8
DOIs	https://doi.org/10.1038/jhg.2014.53
State	Published - Aug 2014
Externally published	Yes

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Guo, M. H., Wu, W. J., Fan, L., Peng, M. S., Yang, J. K., Zhang, W., Hao, F., Xie, H. F., Xiang, L. H., Zheng, M., Guo, Y. N., Song, Q. H., Tu, C. X., Zhong, H., Fan, W. G., Shi, Y. J., Cao, P., Feng, L. Y., Na, M., ... Zhang, Y. P. (2014). No association between y chromosomal haplogroups and severe acne in the Han Chinese population. Journal of Human Genetics, 59(8), 475-476. https://doi.org/10.1038/jhg.2014.53

@article{1485918f20f04536913797d17418252a,

title = "No association between y chromosomal haplogroups and severe acne in the Han Chinese population",

abstract = "Severe acne presents sexual dimorphism in its incidence in Chinese population. It is more prevalent in males. To assess the possible Y chromosomal contribution to severe acne risk in Han Chinese males, we analyzed 2041 Y chromosomal SNPs (Y-SNPs) in 725 severe acne cases and 651 controls retrieved from our recent genome-wide association study data. After data filtering, we assigned 585 cases and 494 controls into 12 Y chromosomal haplogroups based on 307 high-confidence Y-SNPs. No statistically significant difference in the distribution of Y chromosomal haplogroup frequencies was observed between the case and control groups. Our results showed a lack of association between the incidence of severe acne and the different Y chromosomal haplogroup in the Han Chinese population.",

author = "Guo, \{Mei Hua\} and Wu, \{Wen Juan\} and Long Fan and Peng, \{Min Sheng\} and Yang, \{Jian Kang\} and Wen Zhang and Fei Hao and Xie, \{Hong Fu\} and Xiang, \{Lei Hong\} and Min Zheng and Guo, \{Yan Ni\} and Song, \{Qing Hua\} and Tu, \{Cai Xia\} and Hua Zhong and Fan, \{Wen Ge\} and Shi, \{Yue Jun\} and Ping Cao and Feng, \{Lian Yuan\} and Meng Na and Qin Pang and Yang, \{Xiao Yan\} and Cheng Yang and Xi Zou and Li He and Zhang, \{Ya Ping\}",

year = "2014",

month = aug,

doi = "10.1038/jhg.2014.53",

language = "English",

volume = "59",

pages = "475--476",

journal = "Journal of Human Genetics",

issn = "1434-5161",

publisher = "Springer Nature",

number = "8",

}

Guo, MH, Wu, WJ, Fan, L, Peng, MS, Yang, JK, Zhang, W, Hao, F, Xie, HF, Xiang, LH, Zheng, M, Guo, YN, Song, QH, Tu, CX, Zhong, H, Fan, WG, Shi, YJ, Cao, P, Feng, LY, Na, M, Pang, Q, Yang, XY, Yang, C, Zou, X, He, L & Zhang, YP 2014, 'No association between y chromosomal haplogroups and severe acne in the Han Chinese population', Journal of Human Genetics, vol. 59, no. 8, pp. 475-476. https://doi.org/10.1038/jhg.2014.53

TY - JOUR

T1 - No association between y chromosomal haplogroups and severe acne in the Han Chinese population

AU - Guo, Mei Hua

AU - Wu, Wen Juan

AU - Fan, Long

AU - Peng, Min Sheng

AU - Yang, Jian Kang

AU - Zhang, Wen

AU - Hao, Fei

AU - Xie, Hong Fu

AU - Xiang, Lei Hong

AU - Zheng, Min

AU - Guo, Yan Ni

AU - Song, Qing Hua

AU - Tu, Cai Xia

AU - Zhong, Hua

AU - Fan, Wen Ge

AU - Shi, Yue Jun

AU - Cao, Ping

AU - Feng, Lian Yuan

AU - Na, Meng

AU - Pang, Qin

AU - Yang, Xiao Yan

AU - Yang, Cheng

AU - Zou, Xi

AU - He, Li

AU - Zhang, Ya Ping

PY - 2014/8

Y1 - 2014/8

N2 - Severe acne presents sexual dimorphism in its incidence in Chinese population. It is more prevalent in males. To assess the possible Y chromosomal contribution to severe acne risk in Han Chinese males, we analyzed 2041 Y chromosomal SNPs (Y-SNPs) in 725 severe acne cases and 651 controls retrieved from our recent genome-wide association study data. After data filtering, we assigned 585 cases and 494 controls into 12 Y chromosomal haplogroups based on 307 high-confidence Y-SNPs. No statistically significant difference in the distribution of Y chromosomal haplogroup frequencies was observed between the case and control groups. Our results showed a lack of association between the incidence of severe acne and the different Y chromosomal haplogroup in the Han Chinese population.

AB - Severe acne presents sexual dimorphism in its incidence in Chinese population. It is more prevalent in males. To assess the possible Y chromosomal contribution to severe acne risk in Han Chinese males, we analyzed 2041 Y chromosomal SNPs (Y-SNPs) in 725 severe acne cases and 651 controls retrieved from our recent genome-wide association study data. After data filtering, we assigned 585 cases and 494 controls into 12 Y chromosomal haplogroups based on 307 high-confidence Y-SNPs. No statistically significant difference in the distribution of Y chromosomal haplogroup frequencies was observed between the case and control groups. Our results showed a lack of association between the incidence of severe acne and the different Y chromosomal haplogroup in the Han Chinese population.

UR - https://www.scopus.com/pages/publications/84906719485

U2 - 10.1038/jhg.2014.53

DO - 10.1038/jhg.2014.53

M3 - Article

C2 - 25007882

AN - SCOPUS:84906719485

SN - 1434-5161

VL - 59

SP - 475

EP - 476

JO - Journal of Human Genetics

JF - Journal of Human Genetics

IS - 8

ER -

No association between y chromosomal haplogroups and severe acne in the Han Chinese population

Abstract

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