No association between y chromosomal haplogroups and severe acne in the Han Chinese population

Mei Hua Guo; Wen Juan Wu; Long Fan; Min Sheng Peng; Jian Kang Yang; Wen Zhang; Fei Hao; Hong Fu Xie; Lei Hong Xiang; Min Zheng; Yan Ni Guo; Qing Hua Song; Cai Xia Tu; Hua Zhong; Wen Ge Fan; Yue Jun Shi; Ping Cao; Lian Yuan Feng; Meng Na; Qin Pang; Xiao Yan Yang; Cheng Yang; Xi Zou; Li He; Ya Ping Zhang

doi:10.1038/jhg.2014.53

No association between y chromosomal haplogroups and severe acne in the Han Chinese population

Mei Hua Guo, Wen Juan Wu, Long Fan, Min Sheng Peng, Jian Kang Yang, Wen Zhang, Fei Hao, Hong Fu Xie, Lei Hong Xiang, Min Zheng, Yan Ni Guo, Qing Hua Song, Cai Xia Tu, Hua Zhong, Wen Ge Fan, Yue Jun Shi, Ping Cao, Lian Yuan Feng, Meng Na, Qin PangXiao Yan Yang, Cheng Yang, Xi Zou, Li He, Ya Ping Zhang

Research output: Contribution to journal › Article › peer-review

Abstract

Severe acne presents sexual dimorphism in its incidence in Chinese population. It is more prevalent in males. To assess the possible Y chromosomal contribution to severe acne risk in Han Chinese males, we analyzed 2041 Y chromosomal SNPs (Y-SNPs) in 725 severe acne cases and 651 controls retrieved from our recent genome-wide association study data. After data filtering, we assigned 585 cases and 494 controls into 12 Y chromosomal haplogroups based on 307 high-confidence Y-SNPs. No statistically significant difference in the distribution of Y chromosomal haplogroup frequencies was observed between the case and control groups. Our results showed a lack of association between the incidence of severe acne and the different Y chromosomal haplogroup in the Han Chinese population.

Original language	English
Pages (from-to)	475-476
Number of pages	2
Journal	Journal of Human Genetics
Volume	59
Issue number	8
DOIs	https://doi.org/10.1038/jhg.2014.53
State	Published - Aug 2014
Externally published	Yes

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Guo, M. H., Wu, W. J., Fan, L., Peng, M. S., Yang, J. K., Zhang, W., Hao, F., Xie, H. F., Xiang, L. H., Zheng, M., Guo, Y. N., Song, Q. H., Tu, C. X., Zhong, H., Fan, W. G., Shi, Y. J., Cao, P., Feng, L. Y., Na, M., ... Zhang, Y. P. (2014). No association between y chromosomal haplogroups and severe acne in the Han Chinese population. Journal of Human Genetics, 59(8), 475-476. https://doi.org/10.1038/jhg.2014.53

@article{1485918f20f04536913797d17418252a,

title = "No association between y chromosomal haplogroups and severe acne in the Han Chinese population",

abstract = "Severe acne presents sexual dimorphism in its incidence in Chinese population. It is more prevalent in males. To assess the possible Y chromosomal contribution to severe acne risk in Han Chinese males, we analyzed 2041 Y chromosomal SNPs (Y-SNPs) in 725 severe acne cases and 651 controls retrieved from our recent genome-wide association study data. After data filtering, we assigned 585 cases and 494 controls into 12 Y chromosomal haplogroups based on 307 high-confidence Y-SNPs. No statistically significant difference in the distribution of Y chromosomal haplogroup frequencies was observed between the case and control groups. Our results showed a lack of association between the incidence of severe acne and the different Y chromosomal haplogroup in the Han Chinese population.",

author = "Guo, {Mei Hua} and Wu, {Wen Juan} and Long Fan and Peng, {Min Sheng} and Yang, {Jian Kang} and Wen Zhang and Fei Hao and Xie, {Hong Fu} and Xiang, {Lei Hong} and Min Zheng and Guo, {Yan Ni} and Song, {Qing Hua} and Tu, {Cai Xia} and Hua Zhong and Fan, {Wen Ge} and Shi, {Yue Jun} and Ping Cao and Feng, {Lian Yuan} and Meng Na and Qin Pang and Yang, {Xiao Yan} and Cheng Yang and Xi Zou and Li He and Zhang, {Ya Ping}",

year = "2014",

month = aug,

doi = "10.1038/jhg.2014.53",

language = "English",

volume = "59",

pages = "475--476",

journal = "Journal of Human Genetics",

issn = "1434-5161",

publisher = "Springer Nature",

number = "8",

}

Guo, MH, Wu, WJ, Fan, L, Peng, MS, Yang, JK, Zhang, W, Hao, F, Xie, HF, Xiang, LH, Zheng, M, Guo, YN, Song, QH, Tu, CX, Zhong, H, Fan, WG, Shi, YJ, Cao, P, Feng, LY, Na, M, Pang, Q, Yang, XY, Yang, C, Zou, X, He, L & Zhang, YP 2014, 'No association between y chromosomal haplogroups and severe acne in the Han Chinese population', Journal of Human Genetics, vol. 59, no. 8, pp. 475-476. https://doi.org/10.1038/jhg.2014.53

TY - JOUR

T1 - No association between y chromosomal haplogroups and severe acne in the Han Chinese population

AU - Guo, Mei Hua

AU - Wu, Wen Juan

AU - Fan, Long

AU - Peng, Min Sheng

AU - Yang, Jian Kang

AU - Zhang, Wen

AU - Hao, Fei

AU - Xie, Hong Fu

AU - Xiang, Lei Hong

AU - Zheng, Min

AU - Guo, Yan Ni

AU - Song, Qing Hua

AU - Tu, Cai Xia

AU - Zhong, Hua

AU - Fan, Wen Ge

AU - Shi, Yue Jun

AU - Cao, Ping

AU - Feng, Lian Yuan

AU - Na, Meng

AU - Pang, Qin

AU - Yang, Xiao Yan

AU - Yang, Cheng

AU - Zou, Xi

AU - He, Li

AU - Zhang, Ya Ping

PY - 2014/8

Y1 - 2014/8

N2 - Severe acne presents sexual dimorphism in its incidence in Chinese population. It is more prevalent in males. To assess the possible Y chromosomal contribution to severe acne risk in Han Chinese males, we analyzed 2041 Y chromosomal SNPs (Y-SNPs) in 725 severe acne cases and 651 controls retrieved from our recent genome-wide association study data. After data filtering, we assigned 585 cases and 494 controls into 12 Y chromosomal haplogroups based on 307 high-confidence Y-SNPs. No statistically significant difference in the distribution of Y chromosomal haplogroup frequencies was observed between the case and control groups. Our results showed a lack of association between the incidence of severe acne and the different Y chromosomal haplogroup in the Han Chinese population.

AB - Severe acne presents sexual dimorphism in its incidence in Chinese population. It is more prevalent in males. To assess the possible Y chromosomal contribution to severe acne risk in Han Chinese males, we analyzed 2041 Y chromosomal SNPs (Y-SNPs) in 725 severe acne cases and 651 controls retrieved from our recent genome-wide association study data. After data filtering, we assigned 585 cases and 494 controls into 12 Y chromosomal haplogroups based on 307 high-confidence Y-SNPs. No statistically significant difference in the distribution of Y chromosomal haplogroup frequencies was observed between the case and control groups. Our results showed a lack of association between the incidence of severe acne and the different Y chromosomal haplogroup in the Han Chinese population.

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U2 - 10.1038/jhg.2014.53

DO - 10.1038/jhg.2014.53

M3 - Article

C2 - 25007882

AN - SCOPUS:84906719485

SN - 1434-5161

VL - 59

SP - 475

EP - 476

JO - Journal of Human Genetics

JF - Journal of Human Genetics

IS - 8

ER -

No association between y chromosomal haplogroups and severe acne in the Han Chinese population

Abstract

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