No association between low- and high-activity catecholamine-methyl- transferase (COMT) and attention deficit hyperactivity disorder (ADHD) in a sample of Turkish children

Eda Tahir, Sarah Curran, Yanki Yazgan, Fatih Ozbay, Beyazit Cirakoglu, Philip J. Asherson

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

Biochemical and genetic studies of attention deficit hyperactivity disorder (ADHD) suggest that regulation of catecholamine neurotransmission is a key factor in the aetiology of the disorder. In particular, it is postulated that an underactive dopamine system is associated with the disorder. In this study we have tested this hypothesis by screening a clinical sample of Turkish children with the combined subtype of ADHD with a functional variant of catecholamine-methyl-transferase (COMT) that codes for high- and low-activity variants of the enzyme. Using within-family tests of association and linkage in a sample of 72 children, we found no evidence for a genetic association or linkage. We conclude that altered regulation of catecholamines due to this polymorphism does not have a significant main effect on the risk for ADHD in this population. However, it remains feasible that more minor effects or interacting effects with other genes or environment exist. (C) 2000 Wiley-Liss. Inc.

Original languageEnglish
Pages (from-to)285-288
Number of pages4
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume96
Issue number3
DOIs
StatePublished - 12 Jun 2000
Externally publishedYes

Keywords

  • Association study
  • Attention deficit hyperactivity disorder (ADHD)
  • Catecholamine-methyl-transferase (COMT)

Fingerprint

Dive into the research topics of 'No association between low- and high-activity catecholamine-methyl- transferase (COMT) and attention deficit hyperactivity disorder (ADHD) in a sample of Turkish children'. Together they form a unique fingerprint.

Cite this