@article{899ebe7315fa4d9aaf964c59cb38f89d,
title = "No association between circulating concentrations of vitamin D and risk of lung cancer: An analysis in 20 prospective studies in the Lung Cancer Cohort Consortium (LC3)",
abstract = "Background: There is observational evidence suggesting that high vitamin D concentrations may protect against lung cancer. To investigate this hypothesis in detail, we measured circulating vitamin D concentrations in prediagnostic blood from 20 cohorts participating in the Lung Cancer Cohort Consortium (LC3). Patients and methods: The study included 5313 lung cancer cases and 5313 controls. Blood samples for the cases were collected, on average, 5 years before lung cancer diagnosis. Controls were individually matched to the cases by cohort, sex, age, race/ethnicity, date of blood collection, and smoking status in five categories. Liquid chromatography coupled with tandem mass spectrometry was used to separately analyze 25-hydroxyvitamin D2 [25(OH)D2] and 25-hydroxyvitamin D3 [25(OH)D3] and their concentrations were combined to give an overall measure of 25(OH)D. We used conditional logistic regression to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for 25(OH)D as both continuous and categorical variables. Results: Overall, no apparent association between 25(OH)D and risk of lung cancer was observed (multivariable adjusted OR for a doubling in concentration: 0.98, 95% CI: 0.91, 1.06). Similarly, we found no clear evidence of interaction by cohort, sex, age, smoking status, or histology. Conclusion: This study did not support an association between vitamin D concentrations and lung cancer risk.",
keywords = "Case-control, Consortium, Lung cancer, Prospective, Serum 25-hydroxyvitamin D, Vitamin D",
author = "Muller, {D. C.} and Hodge, {A. M.} and A. Fanidi and D. Albanes and Mai, {X. M.} and Shu, {X. O.} and Weinstein, {S. J.} and Larose, {T. L.} and X. Zhang and J. Han and Stampfer, {M. J.} and Smith-Warner, {S. A.} and J. Ma and Gaziano, {J. M.} and Sesso, {H. D.} and Stevens, {V. L.} and McCullough, {M. L.} and Layne, {T. M.} and R. Prentice and M. Pettinger and Thomson, {C. A.} and W. Zheng and Gao, {Y. T.} and N. Rothman and Xiang, {Y. B.} and H. Cai and R. Wang and Yuan, {J. M.} and Koh, {W. P.} and Butler, {L. M.} and Q. Cai and Blot, {W. J.} and J. Wu and Ueland, {P. M.} and O. Midttun and A. Langhammer and K. Hveem and M. Johansson and J. Hultdin and K. Grankvist and Arslan, {A. A.} and {Le Marchand}, L. and G. Severi and M. Johansson and Paul Brennan",
note = "Funding Information: The Lung Cancer Cohort Consortium (LC3) was supported by a grant from the National Cancer Institute, National Institutes of Health (grant number 1U01CA155340-01) and National Health and Medical Research Council Australia (grant number 1050198). DCM was supported by an IARC/Australia Fellowship funded by Cancer Council Australia and a Cancer Research UK Population Research Fellowship (no grant numbers apply). TLL was supported by The Research Council of Norway (grant number 267776/H10). The work of TLL presented in this paper was undertaken during a postdoctoral placement at the International Agency for Research on Cancer, within the framework of an agreement between the Research Council of Norway and the Norwegian University of Science and Technology. The funding organizations had no role in design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript. The WHI program is funded by the National Heart, Lung, and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services through contracts HHSN268201600018C, HHSN2682016000 01C, HHSN268201600002C, HHSN268201600003C, and HHS N268201600004C. Shanghai Womens Health Study was supported by R37 CA070867 and UM1 CA182910 and Shanghai Mens Health Study by R01 CA082729 and UM1 CA173640 from the US National Cancer Institute. Publisher Copyright: {\textcopyright} The Author(s) 2018.",
year = "2018",
month = jun,
day = "1",
doi = "10.1093/annonc/mdy104",
language = "English",
volume = "29",
pages = "1468--1475",
journal = "Annals of Oncology",
issn = "0923-7534",
publisher = "Elsevier Ltd.",
number = "6",
}