No association between antepartum serologic and genital tract evidence of herpes simplex virus-2 coinfection and perinatal HIV-1 transmission

Katherine T. Chen, Ruth E. Tuomala, Clara Chu, Meei Li Huang, D. Heather Watts, Carmen D. Zorrilla, Mary Paul, Ron Hershow, Philip Larussa

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Objective: The purpose of this study was to assess the risk of perinatal HIV-1 transmission in women who are coinfected with herpes simplex virus-2 (HSV-2). Study Design: We performed a nested case-control study of 26 women whose HIV-1 was transmitted to their infants and 52 control subjects whose HIV-1 was not transmitted. We assessed antepartum serologic evidence of HSV-2 by HSV-2 serostatus and genital tract evidence of HSV-2 by presence of HSV-2 DNA. Results: There was no significant association between antepartum serologic evidence of HSV-2 coinfection and the risk of perinatal HIV-1 transmission. There was also no association between antepartum genital tract evidence of HSV-2 coinfection and risk of perinatal HIV-1 transmission. Conclusion: Women who were infected with HIV-1 with antepartum serologic and genital tract evidence of HSV-2 coinfection did not appear to have an increased risk of perinatal HIV-1 transmission. However, further investigations are needed to assess HSV-2 reactivation and the risk of perinatal HIV-1 transmission at the time of delivery.

Original languageEnglish
Pages (from-to)399.e1-399.e5
JournalAmerican Journal of Obstetrics and Gynecology
Volume198
Issue number4
DOIs
StatePublished - Apr 2008
Externally publishedYes

Keywords

  • herpes simplex virus 2 infection
  • perinatal HIV-1 transmission
  • pregnancy
  • transmitted infection

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