No alterations of brain structural asymmetry in major depressive disorder: An ENIGMA consortium analysis

Carolien G.F. De Kovel; Lyubomir Aftanas; André Aleman; Aaron F. Alexander-Bloch; Bernhard T. Baune; Ivan Brack; Robin Bülow; Geraldo Busatto Filho; Angela Carballedo; Colm G. Connolly; Kathryn R. Cullen; Udo Dannlowski; Christopher G. Davey; Danai Dima; Katharina Dohm; Tracy Erwin-Grabner; Thomas Frodl; Cynthia H.Y. Fu; Geoffrey B. Hall; David C. Glahn; Beata Godlewska; Ian H. Gotlib; Roberto Goya-Maldonado; Hans Jörgen Grabe; Nynke A. Groenewold; Dominik Grotegerd; Oliver Gruber; Mathew A. Harris; Ben J. Harrison; Sean N. Hatton; Ian B. Hickie; Tiffany C. Ho; Neda Jahanshad; Tilo Kircher; Bernd Krämer; Axel Krug; Jim Lagopoulos; Elisabeth J. Leehr; Meng Li; Frank P. MacMaster; Glenda MacQueen; Andrew M. McIntosh; Quinn McLellan; Sarah E. Medland; Bryon A. Mueller; Igor Nenadic; Evgeny Osipov; Martina Papmeyer; Maria J. Portella; Liesbeth Reneman; Pedro G.P. Rosa; Matthew D. Sacchet; Knut Schnell; Anouk Schrantee; Kang Sim; Egle Simulionyte; Lisa Sindermann; Aditya Singh; Dan J. Stein; Benjamin N. Ubani; Nic J.A. Van Der Wee; Steven J.A. Van Der Werff; Ilya M. Veer; Yolanda Vives-Gilabert; Henry Völzke; Henrik Walter; Martin Walter; Melinda Westlund Schreiner; Heather Whalley; Nils Winter; Katharina Wittfeld; Tony T. Yang; Dilara Yüksel; Dario Zaremba; Paul M. Thompson; Dick J. Veltman; Lianne Schmaal; Clyde Francks

doi:10.1176/appi.ajp.2019.18101144

No alterations of brain structural asymmetry in major depressive disorder: An ENIGMA consortium analysis

Carolien G.F. De Kovel, Lyubomir Aftanas, André Aleman, Aaron F. Alexander-Bloch, Bernhard T. Baune, Ivan Brack, Robin Bülow, Geraldo Busatto Filho, Angela Carballedo, Colm G. Connolly, Kathryn R. Cullen, Udo Dannlowski, Christopher G. Davey, Danai Dima, Katharina Dohm, Tracy Erwin-Grabner, Thomas Frodl, Cynthia H.Y. Fu, Geoffrey B. Hall, David C. GlahnBeata Godlewska, Ian H. Gotlib, Roberto Goya-Maldonado, Hans Jörgen Grabe, Nynke A. Groenewold, Dominik Grotegerd, Oliver Gruber, Mathew A. Harris, Ben J. Harrison, Sean N. Hatton, Ian B. Hickie, Tiffany C. Ho, Neda Jahanshad, Tilo Kircher, Bernd Krämer, Axel Krug, Jim Lagopoulos, Elisabeth J. Leehr, Meng Li, Frank P. MacMaster, Glenda MacQueen, Andrew M. McIntosh, Quinn McLellan, Sarah E. Medland, Bryon A. Mueller, Igor Nenadic, Evgeny Osipov, Martina Papmeyer, Maria J. Portella, Liesbeth Reneman, Pedro G.P. Rosa, Matthew D. Sacchet, Knut Schnell, Anouk Schrantee, Kang Sim, Egle Simulionyte, Lisa Sindermann, Aditya Singh, Dan J. Stein, Benjamin N. Ubani, Nic J.A. Van Der Wee, Steven J.A. Van Der Werff, Ilya M. Veer, Yolanda Vives-Gilabert, Henry Völzke, Henrik Walter, Martin Walter, Melinda Westlund Schreiner, Heather Whalley, Nils Winter, Katharina Wittfeld, Tony T. Yang, Dilara Yüksel, Dario Zaremba, Paul M. Thompson, Dick J. Veltman, Lianne Schmaal, Clyde Francks

Research output: Contribution to journal › Article › peer-review

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Abstract

Objective: Asymmetry is a subtle but pervasive aspect of the human brain, and it may be altered in several psychiatric conditions. MRI studies have shown subtle differences of brain anatomy between people with major depressive disorder and healthy control subjects, but few studies have specifically examined brain anatomical asymmetry in relation to this disorder, and results from those studies have remained inconclusive. At the functional level, some electroencephalography studies have indicated left fronto-cortical hypoactivity and right parietal hypoactivity in depressive disorders, so aspects of lateralized anatomy may also be affected. The authors used pooled individual-level data from data sets collected around the world to investigate differences in laterality in measures of cortical thickness, cortical surface area, and subcortical volume between individuals with major depression and healthy control subjects. Methods: The authors investigated differences in the laterality of thickness and surface area measures of 34 cerebral cortical regions in 2,256 individuals with major depression and 3,504 control subjects from 31 separate data sets, and they investigated volume asymmetries of eight subcortical structures in 2,540 individuals with major depression and 4,230 control subjects from 32 data sets. T₁-weighted MRI data were processedwith a single protocol using FreeSurfer and the Desikan-Killiany atlas. The large sample size provided 80% power to detect effects of the order of Cohen's d=0.1. Results: The largest effect size (Cohen's d) of major depression diagnosis was 0.085 for the thickness asymmetry of the superior temporal cortex, which was not significant after adjustment for multiple testing. Asymmetry measures were not significantly associated with medication use, acute compared with remitted status, first episode compared with recurrent status, or age at onset. Conclusions: Altered brain macro-anatomical asymmetry may be of little relevance to major depression etiology in most cases.

Original language	English
Pages (from-to)	1039-1049
Number of pages	11
Journal	American Journal of Psychiatry
Volume	176
Issue number	12
DOIs	https://doi.org/10.1176/appi.ajp.2019.18101144
State	Published - 2019
Externally published	Yes

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10.1176/appi.ajp.2019.18101144

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De Kovel, C. G. F., Aftanas, L., Aleman, A., Alexander-Bloch, A. F., Baune, B. T., Brack, I., Bülow, R., Filho, G. B., Carballedo, A., Connolly, C. G., Cullen, K. R., Dannlowski, U., Davey, C. G., Dima, D., Dohm, K., Erwin-Grabner, T., Frodl, T., Fu, C. H. Y., Hall, G. B., ... Francks, C. (2019). No alterations of brain structural asymmetry in major depressive disorder: An ENIGMA consortium analysis. American Journal of Psychiatry, 176(12), 1039-1049. https://doi.org/10.1176/appi.ajp.2019.18101144

@article{d3c641eef9474b45a48cd57dd07484f8,

title = "No alterations of brain structural asymmetry in major depressive disorder: An ENIGMA consortium analysis",

abstract = "Objective: Asymmetry is a subtle but pervasive aspect of the human brain, and it may be altered in several psychiatric conditions. MRI studies have shown subtle differences of brain anatomy between people with major depressive disorder and healthy control subjects, but few studies have specifically examined brain anatomical asymmetry in relation to this disorder, and results from those studies have remained inconclusive. At the functional level, some electroencephalography studies have indicated left fronto-cortical hypoactivity and right parietal hypoactivity in depressive disorders, so aspects of lateralized anatomy may also be affected. The authors used pooled individual-level data from data sets collected around the world to investigate differences in laterality in measures of cortical thickness, cortical surface area, and subcortical volume between individuals with major depression and healthy control subjects. Methods: The authors investigated differences in the laterality of thickness and surface area measures of 34 cerebral cortical regions in 2,256 individuals with major depression and 3,504 control subjects from 31 separate data sets, and they investigated volume asymmetries of eight subcortical structures in 2,540 individuals with major depression and 4,230 control subjects from 32 data sets. T1-weighted MRI data were processedwith a single protocol using FreeSurfer and the Desikan-Killiany atlas. The large sample size provided 80% power to detect effects of the order of Cohen's d=0.1. Results: The largest effect size (Cohen's d) of major depression diagnosis was 0.085 for the thickness asymmetry of the superior temporal cortex, which was not significant after adjustment for multiple testing. Asymmetry measures were not significantly associated with medication use, acute compared with remitted status, first episode compared with recurrent status, or age at onset. Conclusions: Altered brain macro-anatomical asymmetry may be of little relevance to major depression etiology in most cases.",

author = "{De Kovel}, {Carolien G.F.} and Lyubomir Aftanas and Andr{\'e} Aleman and Alexander-Bloch, {Aaron F.} and Baune, {Bernhard T.} and Ivan Brack and Robin B{\"u}low and Filho, {Geraldo Busatto} and Angela Carballedo and Connolly, {Colm G.} and Cullen, {Kathryn R.} and Udo Dannlowski and Davey, {Christopher G.} and Danai Dima and Katharina Dohm and Tracy Erwin-Grabner and Thomas Frodl and Fu, {Cynthia H.Y.} and Hall, {Geoffrey B.} and Glahn, {David C.} and Beata Godlewska and Gotlib, {Ian H.} and Roberto Goya-Maldonado and Grabe, {Hans J{\"o}rgen} and Groenewold, {Nynke A.} and Dominik Grotegerd and Oliver Gruber and Harris, {Mathew A.} and Harrison, {Ben J.} and Hatton, {Sean N.} and Hickie, {Ian B.} and Ho, {Tiffany C.} and Neda Jahanshad and Tilo Kircher and Bernd Kr{\"a}mer and Axel Krug and Jim Lagopoulos and Leehr, {Elisabeth J.} and Meng Li and MacMaster, {Frank P.} and Glenda MacQueen and McIntosh, {Andrew M.} and Quinn McLellan and Medland, {Sarah E.} and Mueller, {Bryon A.} and Igor Nenadic and Evgeny Osipov and Martina Papmeyer and Portella, {Maria J.} and Liesbeth Reneman and Rosa, {Pedro G.P.} and Sacchet, {Matthew D.} and Knut Schnell and Anouk Schrantee and Kang Sim and Egle Simulionyte and Lisa Sindermann and Aditya Singh and Stein, {Dan J.} and Ubani, {Benjamin N.} and {Van Der Wee}, {Nic J.A.} and {Van Der Werff}, {Steven J.A.} and Veer, {Ilya M.} and Yolanda Vives-Gilabert and Henry V{\"o}lzke and Henrik Walter and Martin Walter and Schreiner, {Melinda Westlund} and Heather Whalley and Nils Winter and Katharina Wittfeld and Yang, {Tony T.} and Dilara Y{\"u}ksel and Dario Zaremba and Thompson, {Paul M.} and Veltman, {Dick J.} and Lianne Schmaal and Clyde Francks",

year = "2019",

doi = "10.1176/appi.ajp.2019.18101144",

language = "English",

volume = "176",

pages = "1039--1049",

journal = "American Journal of Psychiatry",

issn = "0002-953X",

publisher = "American Psychiatric Association",

number = "12",

}

De Kovel, CGF, Aftanas, L, Aleman, A, Alexander-Bloch, AF, Baune, BT, Brack, I, Bülow, R, Filho, GB, Carballedo, A, Connolly, CG, Cullen, KR, Dannlowski, U, Davey, CG, Dima, D, Dohm, K, Erwin-Grabner, T, Frodl, T, Fu, CHY, Hall, GB, Glahn, DC, Godlewska, B, Gotlib, IH, Goya-Maldonado, R, Grabe, HJ, Groenewold, NA, Grotegerd, D, Gruber, O, Harris, MA, Harrison, BJ, Hatton, SN, Hickie, IB, Ho, TC, Jahanshad, N, Kircher, T, Krämer, B, Krug, A, Lagopoulos, J, Leehr, EJ, Li, M, MacMaster, FP, MacQueen, G, McIntosh, AM, McLellan, Q, Medland, SE, Mueller, BA, Nenadic, I, Osipov, E, Papmeyer, M, Portella, MJ, Reneman, L, Rosa, PGP, Sacchet, MD, Schnell, K, Schrantee, A, Sim, K, Simulionyte, E, Sindermann, L, Singh, A, Stein, DJ, Ubani, BN, Van Der Wee, NJA, Van Der Werff, SJA, Veer, IM, Vives-Gilabert, Y, Völzke, H, Walter, H, Walter, M, Schreiner, MW, Whalley, H, Winter, N, Wittfeld, K, Yang, TT, Yüksel, D, Zaremba, D, Thompson, PM, Veltman, DJ, Schmaal, L & Francks, C 2019, 'No alterations of brain structural asymmetry in major depressive disorder: An ENIGMA consortium analysis', American Journal of Psychiatry, vol. 176, no. 12, pp. 1039-1049. https://doi.org/10.1176/appi.ajp.2019.18101144

TY - JOUR

T1 - No alterations of brain structural asymmetry in major depressive disorder

T2 - An ENIGMA consortium analysis

AU - De Kovel, Carolien G.F.

AU - Aftanas, Lyubomir

AU - Aleman, André

AU - Alexander-Bloch, Aaron F.

AU - Baune, Bernhard T.

AU - Brack, Ivan

AU - Bülow, Robin

AU - Filho, Geraldo Busatto

AU - Carballedo, Angela

AU - Connolly, Colm G.

AU - Cullen, Kathryn R.

AU - Dannlowski, Udo

AU - Davey, Christopher G.

AU - Dima, Danai

AU - Dohm, Katharina

AU - Erwin-Grabner, Tracy

AU - Frodl, Thomas

AU - Fu, Cynthia H.Y.

AU - Hall, Geoffrey B.

AU - Glahn, David C.

AU - Godlewska, Beata

AU - Gotlib, Ian H.

AU - Goya-Maldonado, Roberto

AU - Grabe, Hans Jörgen

AU - Groenewold, Nynke A.

AU - Grotegerd, Dominik

AU - Gruber, Oliver

AU - Harris, Mathew A.

AU - Harrison, Ben J.

AU - Hatton, Sean N.

AU - Hickie, Ian B.

AU - Ho, Tiffany C.

AU - Jahanshad, Neda

AU - Kircher, Tilo

AU - Krämer, Bernd

AU - Krug, Axel

AU - Lagopoulos, Jim

AU - Leehr, Elisabeth J.

AU - Li, Meng

AU - MacMaster, Frank P.

AU - MacQueen, Glenda

AU - McIntosh, Andrew M.

AU - McLellan, Quinn

AU - Medland, Sarah E.

AU - Mueller, Bryon A.

AU - Nenadic, Igor

AU - Osipov, Evgeny

AU - Papmeyer, Martina

AU - Portella, Maria J.

AU - Reneman, Liesbeth

AU - Rosa, Pedro G.P.

AU - Sacchet, Matthew D.

AU - Schnell, Knut

AU - Schrantee, Anouk

AU - Sim, Kang

AU - Simulionyte, Egle

AU - Sindermann, Lisa

AU - Singh, Aditya

AU - Stein, Dan J.

AU - Ubani, Benjamin N.

AU - Van Der Wee, Nic J.A.

AU - Van Der Werff, Steven J.A.

AU - Veer, Ilya M.

AU - Vives-Gilabert, Yolanda

AU - Völzke, Henry

AU - Walter, Henrik

AU - Walter, Martin

AU - Schreiner, Melinda Westlund

AU - Whalley, Heather

AU - Winter, Nils

AU - Wittfeld, Katharina

AU - Yang, Tony T.

AU - Yüksel, Dilara

AU - Zaremba, Dario

AU - Thompson, Paul M.

AU - Veltman, Dick J.

AU - Schmaal, Lianne

AU - Francks, Clyde

PY - 2019

Y1 - 2019

N2 - Objective: Asymmetry is a subtle but pervasive aspect of the human brain, and it may be altered in several psychiatric conditions. MRI studies have shown subtle differences of brain anatomy between people with major depressive disorder and healthy control subjects, but few studies have specifically examined brain anatomical asymmetry in relation to this disorder, and results from those studies have remained inconclusive. At the functional level, some electroencephalography studies have indicated left fronto-cortical hypoactivity and right parietal hypoactivity in depressive disorders, so aspects of lateralized anatomy may also be affected. The authors used pooled individual-level data from data sets collected around the world to investigate differences in laterality in measures of cortical thickness, cortical surface area, and subcortical volume between individuals with major depression and healthy control subjects. Methods: The authors investigated differences in the laterality of thickness and surface area measures of 34 cerebral cortical regions in 2,256 individuals with major depression and 3,504 control subjects from 31 separate data sets, and they investigated volume asymmetries of eight subcortical structures in 2,540 individuals with major depression and 4,230 control subjects from 32 data sets. T1-weighted MRI data were processedwith a single protocol using FreeSurfer and the Desikan-Killiany atlas. The large sample size provided 80% power to detect effects of the order of Cohen's d=0.1. Results: The largest effect size (Cohen's d) of major depression diagnosis was 0.085 for the thickness asymmetry of the superior temporal cortex, which was not significant after adjustment for multiple testing. Asymmetry measures were not significantly associated with medication use, acute compared with remitted status, first episode compared with recurrent status, or age at onset. Conclusions: Altered brain macro-anatomical asymmetry may be of little relevance to major depression etiology in most cases.

AB - Objective: Asymmetry is a subtle but pervasive aspect of the human brain, and it may be altered in several psychiatric conditions. MRI studies have shown subtle differences of brain anatomy between people with major depressive disorder and healthy control subjects, but few studies have specifically examined brain anatomical asymmetry in relation to this disorder, and results from those studies have remained inconclusive. At the functional level, some electroencephalography studies have indicated left fronto-cortical hypoactivity and right parietal hypoactivity in depressive disorders, so aspects of lateralized anatomy may also be affected. The authors used pooled individual-level data from data sets collected around the world to investigate differences in laterality in measures of cortical thickness, cortical surface area, and subcortical volume between individuals with major depression and healthy control subjects. Methods: The authors investigated differences in the laterality of thickness and surface area measures of 34 cerebral cortical regions in 2,256 individuals with major depression and 3,504 control subjects from 31 separate data sets, and they investigated volume asymmetries of eight subcortical structures in 2,540 individuals with major depression and 4,230 control subjects from 32 data sets. T1-weighted MRI data were processedwith a single protocol using FreeSurfer and the Desikan-Killiany atlas. The large sample size provided 80% power to detect effects of the order of Cohen's d=0.1. Results: The largest effect size (Cohen's d) of major depression diagnosis was 0.085 for the thickness asymmetry of the superior temporal cortex, which was not significant after adjustment for multiple testing. Asymmetry measures were not significantly associated with medication use, acute compared with remitted status, first episode compared with recurrent status, or age at onset. Conclusions: Altered brain macro-anatomical asymmetry may be of little relevance to major depression etiology in most cases.

UR - http://www.scopus.com/inward/record.url?scp=85075265195&partnerID=8YFLogxK

U2 - 10.1176/appi.ajp.2019.18101144

DO - 10.1176/appi.ajp.2019.18101144

M3 - Article

C2 - 31352813

AN - SCOPUS:85075265195

SN - 0002-953X

VL - 176

SP - 1039

EP - 1049

JO - American Journal of Psychiatry

JF - American Journal of Psychiatry

IS - 12

ER -

No alterations of brain structural asymmetry in major depressive disorder: An ENIGMA consortium analysis

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