NMR in cancer. X. A malignancy index to discriminate normal and cancerous tissue

Jason A. Koutcher; Michael Goldsmith; Raymond Damadian

doi:10.1002/1097-0142(197801)41:1<174::AID-CNCR2820410126>3.0.CO;2-2

NMR in cancer. X. A malignancy index to discriminate normal and cancerous tissue

Jason A. Koutcher, Michael Goldsmith, Raymond Damadian

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Proton nuclear magnetic resonance relaxation parameters (T₁, T₂, T_1ρ) were measured on 84 normal and malignant samples of colon, lung and breast tissue at 22.5 MHz. The purpose of this study was to evaluate the ability of NMR measurements to discriminate between normal and malignant tissue. By combining T₁ and T₂ into a normalized NMR malignancy index, it was possible to discriminate malignant and normal tissue in all 36 colon samples, 22 out of 23 breast samples, and 26 out of 29 lung cases. Furthermore, histologically normal tissue adjacent to malignant colonic tissue was found to have an elevated NMR malignancy index comparable to that of malignant colon.

Original language	English
Pages (from-to)	174-182
Number of pages	9
Journal	Cancer
Volume	41
Issue number	1
DOIs	https://doi.org/10.1002/1097-0142(197801)41:1<174::AID-CNCR2820410126>3.0.CO;2-2
State	Published - Jan 1978
Externally published	Yes

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10.1002/1097-0142(197801)41:1<174::AID-CNCR2820410126>3.0.CO;2-2

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title = "NMR in cancer. X. A malignancy index to discriminate normal and cancerous tissue",

abstract = "Proton nuclear magnetic resonance relaxation parameters (T1, T2, T1ρ) were measured on 84 normal and malignant samples of colon, lung and breast tissue at 22.5 MHz. The purpose of this study was to evaluate the ability of NMR measurements to discriminate between normal and malignant tissue. By combining T1 and T2 into a normalized NMR malignancy index, it was possible to discriminate malignant and normal tissue in all 36 colon samples, 22 out of 23 breast samples, and 26 out of 29 lung cases. Furthermore, histologically normal tissue adjacent to malignant colonic tissue was found to have an elevated NMR malignancy index comparable to that of malignant colon.",

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N2 - Proton nuclear magnetic resonance relaxation parameters (T1, T2, T1ρ) were measured on 84 normal and malignant samples of colon, lung and breast tissue at 22.5 MHz. The purpose of this study was to evaluate the ability of NMR measurements to discriminate between normal and malignant tissue. By combining T1 and T2 into a normalized NMR malignancy index, it was possible to discriminate malignant and normal tissue in all 36 colon samples, 22 out of 23 breast samples, and 26 out of 29 lung cases. Furthermore, histologically normal tissue adjacent to malignant colonic tissue was found to have an elevated NMR malignancy index comparable to that of malignant colon.

AB - Proton nuclear magnetic resonance relaxation parameters (T1, T2, T1ρ) were measured on 84 normal and malignant samples of colon, lung and breast tissue at 22.5 MHz. The purpose of this study was to evaluate the ability of NMR measurements to discriminate between normal and malignant tissue. By combining T1 and T2 into a normalized NMR malignancy index, it was possible to discriminate malignant and normal tissue in all 36 colon samples, 22 out of 23 breast samples, and 26 out of 29 lung cases. Furthermore, histologically normal tissue adjacent to malignant colonic tissue was found to have an elevated NMR malignancy index comparable to that of malignant colon.

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NMR in cancer. X. A malignancy index to discriminate normal and cancerous tissue

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