NMDA 受体与肾上腺素受体参与神经精神疾病的 分子机制研究进展

Wen Xin Zhang; Dong Yu Zhou; Yi Han; Ran Ji; Lin Ai; An Xie; Xiao Jing Zhai; Jun Li Cao; Hong Xing Zhang

doi:10.12360/CPB202306014

NMDA 受体与肾上腺素受体参与神经精神疾病的分子机制研究进展

Translated title of the contribution: Research progress on molecular mechanism underlying neuropsychiatric diseases involving NMDA receptor and ₂ adrenergic receptor

Wen Xin Zhang, Dong Yu Zhou, Yi Han, Ran Ji, Lin Ai, An Xie, Xiao Jing Zhai, Jun Li Cao, Hong Xing Zhang

Research output: Contribution to journal › Article › peer-review

Abstract

Glutamate, norepinephrine, and their receptors comprise the glutamatergic and norepinephrine systems, which mu- tually affect each other and play essential roles in mediating vari- ous neuropsychiatric diseases. This paper reviews the functions of N-methyl-D-aspartate receptor (NMDA-R) and x2-adrenergic receptor (x2-AR) and their functional crosstalk at the molecular level in brain in common neuropsychiatric diseases, which would benefit our understanding of neuropathophysiology of psychiatric diseases, drug development and optimization of clinical neuro- psychopharmacology.

Translated title of the contribution	Research progress on molecular mechanism underlying neuropsychiatric diseases involving NMDA receptor and ₂ adrenergic receptor
Original language	Chinese (Traditional)
Pages (from-to)	2206-2212
Number of pages	7
Journal	Chinese Pharmacological Bulletin
Volume	40
Issue number	12
DOIs	https://doi.org/10.12360/CPB202306014
State	Published - Dec 2024
Externally published	Yes

Keywords

Alzhei- mer's disease
N-methyl-D-aspartate receptor
alpha 2 adrenergic receptor
brain-derived neurotrophic factor
depression
neurobiology

Access to Document

10.12360/CPB202306014

Cite this

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title = "NMDA 受体与肾上腺素受体参与神经精神疾病的分子机制研究进展",

abstract = "Glutamate, norepinephrine, and their receptors comprise the glutamatergic and norepinephrine systems, which mu- tually affect each other and play essential roles in mediating vari- ous neuropsychiatric diseases. This paper reviews the functions of N-methyl-D-aspartate receptor (NMDA-R) and x2-adrenergic receptor (x2-AR) and their functional crosstalk at the molecular level in brain in common neuropsychiatric diseases, which would benefit our understanding of neuropathophysiology of psychiatric diseases, drug development and optimization of clinical neuro- psychopharmacology.",

keywords = "Alzhei- mer's disease, N-methyl-D-aspartate receptor, alpha 2 adrenergic receptor, brain-derived neurotrophic factor, depression, neurobiology",

author = "Zhang, {Wen Xin} and Zhou, {Dong Yu} and Yi Han and Ran Ji and Lin Ai and An Xie and Zhai, {Xiao Jing} and Cao, {Jun Li} and Zhang, {Hong Xing}",

year = "2024",

month = dec,

doi = "10.12360/CPB202306014",

language = "Chinese (Traditional)",

volume = "40",

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AU - Zhang, Wen Xin

AU - Zhou, Dong Yu

AU - Han, Yi

AU - Ji, Ran

AU - Ai, Lin

AU - Xie, An

AU - Zhai, Xiao Jing

AU - Cao, Jun Li

AU - Zhang, Hong Xing

PY - 2024/12

Y1 - 2024/12

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AB - Glutamate, norepinephrine, and their receptors comprise the glutamatergic and norepinephrine systems, which mu- tually affect each other and play essential roles in mediating vari- ous neuropsychiatric diseases. This paper reviews the functions of N-methyl-D-aspartate receptor (NMDA-R) and x2-adrenergic receptor (x2-AR) and their functional crosstalk at the molecular level in brain in common neuropsychiatric diseases, which would benefit our understanding of neuropathophysiology of psychiatric diseases, drug development and optimization of clinical neuro- psychopharmacology.

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KW - N-methyl-D-aspartate receptor

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KW - neurobiology

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