Nitrophenyl-based caged neurotransmitters

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Nitroaromatic photochemical protecting groups were developed for organic synthesis in 1966. Since the early 1990s, this type of chromophore has been used by neuroscientists to liberate a wide variety of amino acid neurotransmitters such as ACh, glutamate, GABA, and glycine, among others. Since 2001, several laboratories have used two-photon excitation of nitroaromatic cages for highly localized uncaging of glutamate in acute brain slices.

Original languageEnglish
Pages (from-to)584-590
Number of pages7
JournalCold Spring Harbor Protocols
Issue number6
StatePublished - 2014
Externally publishedYes


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