Nitrogen bisphosphonate-induced orbital inflammatory disease: Gamma delta T cells - A report and review of 2 cases

Monisha M. Vora, I. Rand Rodgers, Scott Uretsky

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

With the increased use of nitrogen bisphosphonate therapy for osteoporosis, multiple myeloma, metastatic prostate carcinoma, and Paget disease, it is now recognized that orbital inflammation is a potential sequelae of treatment. To date, 15 isolated cases of orbital inflammation exist in the literature with additional 2 cases reported herein. While the precise triggering mechanism for orbital inflammation is not definitively understood, it appears that a regulatory response from gamma delta T cells is the most likely causative factor. Nitrogen bisphosphonates are a causative agent of orbital inflammatory disease. These case reports adhered to the principles of Helsinki and the Health Insurance Portability and Accountability Act.

Original languageEnglish
Pages (from-to)e84-e85
JournalOphthalmic Plastic and Reconstructive Surgery
Volume30
Issue number4
DOIs
StatePublished - 2014

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