TY - JOUR
T1 - Nitrogen bisphosphonate-induced orbital inflammatory disease
T2 - Gamma delta T cells - A report and review of 2 cases
AU - Vora, Monisha M.
AU - Rodgers, I. Rand
AU - Uretsky, Scott
PY - 2014
Y1 - 2014
N2 - With the increased use of nitrogen bisphosphonate therapy for osteoporosis, multiple myeloma, metastatic prostate carcinoma, and Paget disease, it is now recognized that orbital inflammation is a potential sequelae of treatment. To date, 15 isolated cases of orbital inflammation exist in the literature with additional 2 cases reported herein. While the precise triggering mechanism for orbital inflammation is not definitively understood, it appears that a regulatory response from gamma delta T cells is the most likely causative factor. Nitrogen bisphosphonates are a causative agent of orbital inflammatory disease. These case reports adhered to the principles of Helsinki and the Health Insurance Portability and Accountability Act.
AB - With the increased use of nitrogen bisphosphonate therapy for osteoporosis, multiple myeloma, metastatic prostate carcinoma, and Paget disease, it is now recognized that orbital inflammation is a potential sequelae of treatment. To date, 15 isolated cases of orbital inflammation exist in the literature with additional 2 cases reported herein. While the precise triggering mechanism for orbital inflammation is not definitively understood, it appears that a regulatory response from gamma delta T cells is the most likely causative factor. Nitrogen bisphosphonates are a causative agent of orbital inflammatory disease. These case reports adhered to the principles of Helsinki and the Health Insurance Portability and Accountability Act.
UR - http://www.scopus.com/inward/record.url?scp=84905913876&partnerID=8YFLogxK
U2 - 10.1097/IOP.0b013e31829f3b46
DO - 10.1097/IOP.0b013e31829f3b46
M3 - Review article
AN - SCOPUS:84905913876
SN - 0740-9303
VL - 30
SP - e84-e85
JO - Ophthalmic Plastic and Reconstructive Surgery
JF - Ophthalmic Plastic and Reconstructive Surgery
IS - 4
ER -