Nitric oxide's reactions with hemoglobin: A view through the SNO-storm

Mark T. Gladwin, Jack R. Lancaster, Bruce A. Freeman, Alan N. Schechter

Research output: Contribution to journalReview articlepeer-review

255 Scopus citations


S-nitroso-hemoglobin (SNOHb) has been proposed to regulate blood flow and tissue oxygenation through allosterically controlled binding and delivery of nitric oxide (NO) and oxygen in the vasculature. This precept and the experiments that test it have provoked both ardent support and expanding dissent. An alternative view suggests that a physiologically tightly regulated balance of NO scavenging by hemoglobin and NO production by endothelial cells determines NO bioavailability.

Original languageEnglish
Pages (from-to)496-500
Number of pages5
JournalNature Medicine
Issue number5
StatePublished - 1 May 2003
Externally publishedYes


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