Nitric oxide derived from L-arginine modulates microvessel function in skeletal muscle

M. G. Persson; L. E. Gustafsson; N. P. Wiklund; P. Hedqvist; S. Mon cada

Nitric oxide derived from L-arginine modulates microvessel function in skeletal muscle

M. G. Persson, L. E. Gustafsson, N. P. Wiklund, P. Hedqvist, S. Mon cada

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

In the rabbit skeletal muscle microcirculation in vivo N(G)-monomethyl-L-arginine (L-NMMA) applied topically dose-dependently and stereospecifically constricted microvessels. Vasoconstriction induced by L-NMMA was prevented by L-arginine. Vasodilatation induced by acetylcholine was significantly inhibited by L-NMMA, whereas vasodilatation induced by adenosine or sodium nitroprusside remained unchanged. Functional hyperaemia was unaffected by L-NMMA. Aggregates of platelets and white blood cells were observed in venules during superfusion with L-NMMA. The present results suggest that endogenous nitric oxide (NO) formed from L-arginine is a modulator of microvascular tone and platelet and white cell-vessel wall interaction in vivo.

Original language	English
Title of host publication	Nitric oxide from L-arginine
Subtitle of host publication	a bioregulatory system: proceedings of a Symposium on Biological Importance of Nitric Oxide. ICS897
Editors	S. Moncada, E.A. Higgs, S. Moncada, E.A. Higgs
Publisher	Elsevier Science Publishers B.V.
Pages	171-175
Number of pages	5
ISBN (Print)	0444811540
State	Published - 1990
Externally published	Yes
Event	A Symposium on Biological Importance of Nitric Oxide - Duration: 14 Sep 1989 → 15 Sep 1989

Publication series

Name	Nitric oxide from L-arginine: a bioregulatory system: proceedings of a Symposium on Biological Importance of Nitric Oxide. ICS897

Conference

Conference	A Symposium on Biological Importance of Nitric Oxide
Period	14/09/89 → 15/09/89

Cite this

Persson, M. G., Gustafsson, L. E., Wiklund, N. P., Hedqvist, P., & Mon cada, S. (1990). Nitric oxide derived from L-arginine modulates microvessel function in skeletal muscle. In S. Moncada, E. A. Higgs, S. Moncada, & E. A. Higgs (Eds.), Nitric oxide from L-arginine: a bioregulatory system: proceedings of a Symposium on Biological Importance of Nitric Oxide. ICS897 (pp. 171-175). (Nitric oxide from L-arginine: a bioregulatory system: proceedings of a Symposium on Biological Importance of Nitric Oxide. ICS897). Elsevier Science Publishers B.V..

Persson, M. G. ; Gustafsson, L. E. ; Wiklund, N. P. et al. / Nitric oxide derived from L-arginine modulates microvessel function in skeletal muscle. Nitric oxide from L-arginine: a bioregulatory system: proceedings of a Symposium on Biological Importance of Nitric Oxide. ICS897. editor / S. Moncada ; E.A. Higgs ; S. Moncada ; E.A. Higgs. Elsevier Science Publishers B.V., 1990. pp. 171-175 (Nitric oxide from L-arginine: a bioregulatory system: proceedings of a Symposium on Biological Importance of Nitric Oxide. ICS897).

@inproceedings{a5b52bcfcc634a7c9e360885eccabfa4,

title = "Nitric oxide derived from L-arginine modulates microvessel function in skeletal muscle",

abstract = "In the rabbit skeletal muscle microcirculation in vivo N(G)-monomethyl-L-arginine (L-NMMA) applied topically dose-dependently and stereospecifically constricted microvessels. Vasoconstriction induced by L-NMMA was prevented by L-arginine. Vasodilatation induced by acetylcholine was significantly inhibited by L-NMMA, whereas vasodilatation induced by adenosine or sodium nitroprusside remained unchanged. Functional hyperaemia was unaffected by L-NMMA. Aggregates of platelets and white blood cells were observed in venules during superfusion with L-NMMA. The present results suggest that endogenous nitric oxide (NO) formed from L-arginine is a modulator of microvascular tone and platelet and white cell-vessel wall interaction in vivo.",

author = "Persson, {M. G.} and Gustafsson, {L. E.} and Wiklund, {N. P.} and P. Hedqvist and {Mon cada}, S.",

year = "1990",

language = "English",

isbn = "0444811540",

series = "Nitric oxide from L-arginine: a bioregulatory system: proceedings of a Symposium on Biological Importance of Nitric Oxide. ICS897",

publisher = "Elsevier Science Publishers B.V.",

pages = "171--175",

editor = "S. Moncada and E.A. Higgs and S. Moncada and E.A. Higgs",

booktitle = "Nitric oxide from L-arginine",

note = "A Symposium on Biological Importance of Nitric Oxide ; Conference date: 14-09-1989 Through 15-09-1989",

}

Persson, MG, Gustafsson, LE, Wiklund, NP, Hedqvist, P & Mon cada, S 1990, Nitric oxide derived from L-arginine modulates microvessel function in skeletal muscle. in S Moncada, EA Higgs, S Moncada & EA Higgs (eds), Nitric oxide from L-arginine: a bioregulatory system: proceedings of a Symposium on Biological Importance of Nitric Oxide. ICS897. Nitric oxide from L-arginine: a bioregulatory system: proceedings of a Symposium on Biological Importance of Nitric Oxide. ICS897, Elsevier Science Publishers B.V., pp. 171-175, A Symposium on Biological Importance of Nitric Oxide, 14/09/89.

Nitric oxide derived from L-arginine modulates microvessel function in skeletal muscle. / Persson, M. G.; Gustafsson, L. E.; Wiklund, N. P. et al.
Nitric oxide from L-arginine: a bioregulatory system: proceedings of a Symposium on Biological Importance of Nitric Oxide. ICS897. ed. / S. Moncada; E.A. Higgs; S. Moncada; E.A. Higgs. Elsevier Science Publishers B.V., 1990. p. 171-175 (Nitric oxide from L-arginine: a bioregulatory system: proceedings of a Symposium on Biological Importance of Nitric Oxide. ICS897).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Nitric oxide derived from L-arginine modulates microvessel function in skeletal muscle

AU - Persson, M. G.

AU - Gustafsson, L. E.

AU - Wiklund, N. P.

AU - Hedqvist, P.

AU - Mon cada, S.

PY - 1990

Y1 - 1990

N2 - In the rabbit skeletal muscle microcirculation in vivo N(G)-monomethyl-L-arginine (L-NMMA) applied topically dose-dependently and stereospecifically constricted microvessels. Vasoconstriction induced by L-NMMA was prevented by L-arginine. Vasodilatation induced by acetylcholine was significantly inhibited by L-NMMA, whereas vasodilatation induced by adenosine or sodium nitroprusside remained unchanged. Functional hyperaemia was unaffected by L-NMMA. Aggregates of platelets and white blood cells were observed in venules during superfusion with L-NMMA. The present results suggest that endogenous nitric oxide (NO) formed from L-arginine is a modulator of microvascular tone and platelet and white cell-vessel wall interaction in vivo.

AB - In the rabbit skeletal muscle microcirculation in vivo N(G)-monomethyl-L-arginine (L-NMMA) applied topically dose-dependently and stereospecifically constricted microvessels. Vasoconstriction induced by L-NMMA was prevented by L-arginine. Vasodilatation induced by acetylcholine was significantly inhibited by L-NMMA, whereas vasodilatation induced by adenosine or sodium nitroprusside remained unchanged. Functional hyperaemia was unaffected by L-NMMA. Aggregates of platelets and white blood cells were observed in venules during superfusion with L-NMMA. The present results suggest that endogenous nitric oxide (NO) formed from L-arginine is a modulator of microvascular tone and platelet and white cell-vessel wall interaction in vivo.

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M3 - Conference contribution

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T3 - Nitric oxide from L-arginine: a bioregulatory system: proceedings of a Symposium on Biological Importance of Nitric Oxide. ICS897

SP - 171

EP - 175

BT - Nitric oxide from L-arginine

A2 - Moncada, S.

A2 - Higgs, E.A.

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A2 - Higgs, E.A.

PB - Elsevier Science Publishers B.V.

T2 - A Symposium on Biological Importance of Nitric Oxide

Y2 - 14 September 1989 through 15 September 1989

ER -

Persson MG, Gustafsson LE, Wiklund NP, Hedqvist P, Mon cada S. Nitric oxide derived from L-arginine modulates microvessel function in skeletal muscle. In Moncada S, Higgs EA, Moncada S, Higgs EA, editors, Nitric oxide from L-arginine: a bioregulatory system: proceedings of a Symposium on Biological Importance of Nitric Oxide. ICS897. Elsevier Science Publishers B.V. 1990. p. 171-175. (Nitric oxide from L-arginine: a bioregulatory system: proceedings of a Symposium on Biological Importance of Nitric Oxide. ICS897).

Nitric oxide derived from L-arginine modulates microvessel function in skeletal muscle

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