Nimodipine reduction of naltrexone-precipitated locus coeruleus activation and abstinence behavior in morphine-dependent rats

John H. Krystal, Sally Compere, Eric J. Nestler, Kurt Rasmussen

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Single-unit recordings in anesthetized animals revealed that the L-type calcium channel antagonist, nimodipine (10 mg/kg), attenuated the activation of locus coeruleus neurons produced by naltrexone in opiate-dependent rats. Nimodipine also dose-dependently (1 mg/kg, 10 mg/kg, IP) inhibited the display of naloxone-precipitated withdrawal behaviors with a time course similar to that of nimodipine effects on the locus coeruleus. These data suggest that nimodipine may suppress opiate withdrawal via noradrenergic mechanisms.

Original languageEnglish
Pages (from-to)863-866
Number of pages4
JournalPhysiology and Behavior
Volume59
Issue number4-5
DOIs
StatePublished - 1996
Externally publishedYes

Keywords

  • Electrophysiology
  • Locus coeruleus
  • Morphine
  • Naltrexone
  • Nimodipine
  • Opiate
  • Withdrawal

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