Nicardipine infusion for postoperative hypertension after surgery of the head and neck

N. A. Halpern, R. N. Sladen, J. S. Goldberg, C. Neely, M. Wood, M. Alicea, L. R. Krakoff, R. Greenstein

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


The therapy of postoperative hypertension (POH) after head and neck surgery was evaluated in a prospective, randomized, double-blind trial. Nicardipine hydrochloride, a Ca channel-blocker for iv use, was compared with placebo. Patients were initially randomized to receive nicardipine infusion or placebo. Those not responding to placebo were given nicardipine infusion on an open basis. Hypertension was significantly better controlled in patients treated with nicardipine infusion compared with placebo (83% vs. 22%, p < .002). Subsequently, six (86%) of seven of the placebo failures were successvully treated with nicardipine. There were no significant complications in either group. We conclude that the titratable infusion of nicardipine is an effective and safe method for the control of POH after surgery of the head and neck. Further studies are now warranted comparing nicardipine with other drugs currently used to treat this condition.

Original languageEnglish
Pages (from-to)950-955
Number of pages6
JournalCritical Care Medicine
Issue number9
StatePublished - 1990
Externally publishedYes


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