TY - JOUR
T1 - NF-κB Participates in Mouse Hair Cycle Control and Plays Distinct Roles in the Various Pelage Hair Follicle Types
AU - Krieger, Karsten
AU - Millar, Sarah E.
AU - Mikuda, Nadine
AU - Krahn, Inge
AU - Kloepper, Jennifer E.
AU - Bertolini, Marta
AU - Scheidereit, Claus
AU - Paus, Ralf
AU - Schmidt-Ullrich, Ruth
N1 - Publisher Copyright:
© 2017 The Authors
PY - 2018/2
Y1 - 2018/2
N2 - The transcription factor NF-κB controls key features of hair follicle (HF) development, but the role of NF-κB in adult HF cycle regulation remains obscure. Using NF-κB reporter mouse models, strong NF-κB activity was detected in the secondary hair germ of late telogen and early anagen HFs, suggesting a potential role for NF-κB in HF stem/progenitor cell activation during anagen induction. At mid-anagen, NF-κB activity was observed in the inner root sheath and unilaterally clustered in the HF matrix, which indicates that NF-κB activity is also involved in hair fiber morphogenesis during HF cycling. A mouse model with inducible NF-κB suppression in the epithelium revealed pelage hair-type−dependent functions of NF-κB in cycling HFs. NF-κB participates in telogen−anagen transition in awl and zigzag HFs, and is required for zigzag hair bending and guard HF cycling. Interestingly, zigzag hair shaft bending depends on noncanonical NF-κB signaling, which previously has only been associated with lymphoid cell biology. Furthermore, loss of guard HF cycling suggests that in this particular hair type, NF-κB is indispensable for stem cell activation, maintenance, and/or growth.
AB - The transcription factor NF-κB controls key features of hair follicle (HF) development, but the role of NF-κB in adult HF cycle regulation remains obscure. Using NF-κB reporter mouse models, strong NF-κB activity was detected in the secondary hair germ of late telogen and early anagen HFs, suggesting a potential role for NF-κB in HF stem/progenitor cell activation during anagen induction. At mid-anagen, NF-κB activity was observed in the inner root sheath and unilaterally clustered in the HF matrix, which indicates that NF-κB activity is also involved in hair fiber morphogenesis during HF cycling. A mouse model with inducible NF-κB suppression in the epithelium revealed pelage hair-type−dependent functions of NF-κB in cycling HFs. NF-κB participates in telogen−anagen transition in awl and zigzag HFs, and is required for zigzag hair bending and guard HF cycling. Interestingly, zigzag hair shaft bending depends on noncanonical NF-κB signaling, which previously has only been associated with lymphoid cell biology. Furthermore, loss of guard HF cycling suggests that in this particular hair type, NF-κB is indispensable for stem cell activation, maintenance, and/or growth.
UR - http://www.scopus.com/inward/record.url?scp=85041674493&partnerID=8YFLogxK
U2 - 10.1016/j.jid.2017.08.042
DO - 10.1016/j.jid.2017.08.042
M3 - Article
C2 - 28942365
AN - SCOPUS:85041674493
SN - 0022-202X
VL - 138
SP - 256
EP - 264
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
IS - 2
ER -