NewProt - A protein engineering portal

Andreas Schwarte; Maika Genz; Lilly Skalden; Alberto Nobili; Clare Vickers; Okke Melse; Remko Kuipers; Henk Jan Joosten; Jan Stourac; Jaroslav Bendl; Jon Black; Peter Haase; Coos Baakman; Jiri Damborsky; Uwe Bornscheuer; Gert Vriend; Hanka Venselaar

doi:10.1093/protein/gzx024

NewProt - A protein engineering portal

Andreas Schwarte
, Maika Genz
, Lilly Skalden
, Alberto Nobili
, Clare Vickers
, Okke Melse
, Remko Kuipers
, Henk Jan Joosten
, Jan Stourac
, Jaroslav Bendl
, Jon Black
, Peter Haase
, Coos Baakman
, Jiri Damborsky
, Uwe Bornscheuer
, Gert Vriend
, Hanka Venselaar

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The NewProt protein engineering portal is a one-stop-shop for in silico protein engineering. It gives access to a large number of servers that compute a wide variety of protein structure characteristics supporting work on the modification of proteins through the introduction of (multiple) point mutations. The results can be inspected through multiple visualizers. The HOPE software is included to indicate mutations with possible undesired side effects. The Hotspot Wizard software is embedded for the design of mutations that modify a proteins' activity, specificity, or stability.

Original language	English
Pages (from-to)	441-447
Number of pages	7
Journal	Protein Engineering, Design and Selection
Volume	30
Issue number	6
DOIs	https://doi.org/10.1093/protein/gzx024
State	Published - 1 Jun 2017
Externally published	Yes

Keywords

mutant analysis
portal
protein design
protein engineering
web server

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10.1093/protein/gzx024

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title = "NewProt - A protein engineering portal",

abstract = "The NewProt protein engineering portal is a one-stop-shop for in silico protein engineering. It gives access to a large number of servers that compute a wide variety of protein structure characteristics supporting work on the modification of proteins through the introduction of (multiple) point mutations. The results can be inspected through multiple visualizers. The HOPE software is included to indicate mutations with possible undesired side effects. The Hotspot Wizard software is embedded for the design of mutations that modify a proteins' activity, specificity, or stability.",

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doi = "10.1093/protein/gzx024",

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T1 - NewProt - A protein engineering portal

AU - Schwarte, Andreas

AU - Genz, Maika

AU - Skalden, Lilly

AU - Nobili, Alberto

AU - Vickers, Clare

AU - Melse, Okke

AU - Kuipers, Remko

AU - Joosten, Henk Jan

AU - Stourac, Jan

AU - Bendl, Jaroslav

AU - Black, Jon

AU - Haase, Peter

AU - Baakman, Coos

AU - Damborsky, Jiri

AU - Bornscheuer, Uwe

AU - Vriend, Gert

AU - Venselaar, Hanka

PY - 2017/6/1

Y1 - 2017/6/1

N2 - The NewProt protein engineering portal is a one-stop-shop for in silico protein engineering. It gives access to a large number of servers that compute a wide variety of protein structure characteristics supporting work on the modification of proteins through the introduction of (multiple) point mutations. The results can be inspected through multiple visualizers. The HOPE software is included to indicate mutations with possible undesired side effects. The Hotspot Wizard software is embedded for the design of mutations that modify a proteins' activity, specificity, or stability.

AB - The NewProt protein engineering portal is a one-stop-shop for in silico protein engineering. It gives access to a large number of servers that compute a wide variety of protein structure characteristics supporting work on the modification of proteins through the introduction of (multiple) point mutations. The results can be inspected through multiple visualizers. The HOPE software is included to indicate mutations with possible undesired side effects. The Hotspot Wizard software is embedded for the design of mutations that modify a proteins' activity, specificity, or stability.

KW - mutant analysis

KW - portal

KW - protein design

KW - protein engineering

KW - web server

UR - https://www.scopus.com/pages/publications/85022182157

U2 - 10.1093/protein/gzx024

DO - 10.1093/protein/gzx024

M3 - Article

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AN - SCOPUS:85022182157

SN - 1741-0126

VL - 30

SP - 441

EP - 447

JO - Protein Engineering, Design and Selection

JF - Protein Engineering, Design and Selection

IS - 6

ER -

NewProt - A protein engineering portal

Abstract

Keywords

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