Newcastle disease virus-vectored H7 and H5 live vaccines protect chickens from challenge with H7N9 or H5N1 avian influenza viruses

Qinfang Liu; Ignacio Mena; Jingjiao Ma; Bhupinder Bawa; Florian Krammer; Young S. Lyoo; Yuekun Lang; Igor Morozov; Gusti Ngurah Mahardika; Wenjun Ma; Adolfo García-Sastre; Juergen A. Richt

doi:10.1128/JVI.00031-15

Newcastle disease virus-vectored H7 and H5 live vaccines protect chickens from challenge with H7N9 or H5N1 avian influenza viruses

Qinfang Liu
, Ignacio Mena
, Jingjiao Ma
, Bhupinder Bawa
, Florian Krammer
, Young S. Lyoo
, Yuekun Lang
, Igor Morozov
, Gusti Ngurah Mahardika
, Wenjun Ma
, Adolfo García-Sastre
, Juergen A. Richt

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

Sporadic human infections by a novel H7N9 virus occurred over a large geographic region in China. In this study, we show that Newcastle disease virus (NDV)-vectored H7 (NDV-H7) and NDV-H5 vaccines are able to induce antibodies with high hemagglutination inhibition (HI) titers and completely protect chickens from challenge with the novel H7N9 or highly pathogenic H5N1 viruses, respectively. Notably, a baculovirus-expressed H7 protein failed to protect chickens from H7N9 virus infection.

Original language	English
Pages (from-to)	6994-7006
Number of pages	13
Journal	Journal of Virology
Volume	89
Issue number	14
DOIs	https://doi.org/10.1128/JVI.00031-15
State	Published - 2015

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title = "Newcastle disease virus-vectored H7 and H5 live vaccines protect chickens from challenge with H7N9 or H5N1 avian influenza viruses",

abstract = "Sporadic human infections by a novel H7N9 virus occurred over a large geographic region in China. In this study, we show that Newcastle disease virus (NDV)-vectored H7 (NDV-H7) and NDV-H5 vaccines are able to induce antibodies with high hemagglutination inhibition (HI) titers and completely protect chickens from challenge with the novel H7N9 or highly pathogenic H5N1 viruses, respectively. Notably, a baculovirus-expressed H7 protein failed to protect chickens from H7N9 virus infection.",

author = "Qinfang Liu and Ignacio Mena and Jingjiao Ma and Bhupinder Bawa and Florian Krammer and Lyoo, \{Young S.\} and Yuekun Lang and Igor Morozov and Mahardika, \{Gusti Ngurah\} and Wenjun Ma and Adolfo Garc{\'i}a-Sastre and Richt, \{Juergen A.\}",

note = "Publisher Copyright: {\textcopyright} 2015, American Society for Microbiology.",

year = "2015",

doi = "10.1128/JVI.00031-15",

language = "English",

volume = "89",

pages = "6994--7006",

journal = "Journal of Virology",

issn = "0022-538X",

publisher = "American Society for Microbiology",

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TY - JOUR

T1 - Newcastle disease virus-vectored H7 and H5 live vaccines protect chickens from challenge with H7N9 or H5N1 avian influenza viruses

AU - Liu, Qinfang

AU - Mena, Ignacio

AU - Ma, Jingjiao

AU - Bawa, Bhupinder

AU - Krammer, Florian

AU - Lyoo, Young S.

AU - Lang, Yuekun

AU - Morozov, Igor

AU - Mahardika, Gusti Ngurah

AU - Ma, Wenjun

AU - García-Sastre, Adolfo

AU - Richt, Juergen A.

PY - 2015

Y1 - 2015

N2 - Sporadic human infections by a novel H7N9 virus occurred over a large geographic region in China. In this study, we show that Newcastle disease virus (NDV)-vectored H7 (NDV-H7) and NDV-H5 vaccines are able to induce antibodies with high hemagglutination inhibition (HI) titers and completely protect chickens from challenge with the novel H7N9 or highly pathogenic H5N1 viruses, respectively. Notably, a baculovirus-expressed H7 protein failed to protect chickens from H7N9 virus infection.

AB - Sporadic human infections by a novel H7N9 virus occurred over a large geographic region in China. In this study, we show that Newcastle disease virus (NDV)-vectored H7 (NDV-H7) and NDV-H5 vaccines are able to induce antibodies with high hemagglutination inhibition (HI) titers and completely protect chickens from challenge with the novel H7N9 or highly pathogenic H5N1 viruses, respectively. Notably, a baculovirus-expressed H7 protein failed to protect chickens from H7N9 virus infection.

UR - https://www.scopus.com/pages/publications/84931035985

U2 - 10.1128/JVI.00031-15

DO - 10.1128/JVI.00031-15

M3 - Article

C2 - 25926639

AN - SCOPUS:84931035985

SN - 0022-538X

VL - 89

SP - 6994

EP - 7006

JO - Journal of Virology

JF - Journal of Virology

IS - 14

ER -

Newcastle disease virus-vectored H7 and H5 live vaccines protect chickens from challenge with H7N9 or H5N1 avian influenza viruses

Abstract

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