Newcastle disease virus-vectored H7 and H5 live vaccines protect chickens from challenge with H7N9 or H5N1 avian influenza viruses

Qinfang Liu; Ignacio Mena; Jingjiao Ma; Bhupinder Bawa; Florian Krammer; Young S. Lyoo; Yuekun Lang; Igor Morozov; Gusti Ngurah Mahardika; Wenjun Ma; Adolfo García-Sastre; Juergen A. Richt

doi:10.1128/JVI.00031-15

Newcastle disease virus-vectored H7 and H5 live vaccines protect chickens from challenge with H7N9 or H5N1 avian influenza viruses

Qinfang Liu, Ignacio Mena, Jingjiao Ma, Bhupinder Bawa, Florian Krammer, Young S. Lyoo, Yuekun Lang, Igor Morozov, Gusti Ngurah Mahardika, Wenjun Ma, Adolfo García-Sastre, Juergen A. Richt

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53 Scopus citations

Abstract

Sporadic human infections by a novel H7N9 virus occurred over a large geographic region in China. In this study, we show that Newcastle disease virus (NDV)-vectored H7 (NDV-H7) and NDV-H5 vaccines are able to induce antibodies with high hemagglutination inhibition (HI) titers and completely protect chickens from challenge with the novel H7N9 or highly pathogenic H5N1 viruses, respectively. Notably, a baculovirus-expressed H7 protein failed to protect chickens from H7N9 virus infection.

Original language	English
Pages (from-to)	6994-7006
Number of pages	13
Journal	Journal of Virology
Volume	89
Issue number	14
DOIs	https://doi.org/10.1128/JVI.00031-15
State	Published - 2015

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title = "Newcastle disease virus-vectored H7 and H5 live vaccines protect chickens from challenge with H7N9 or H5N1 avian influenza viruses",

abstract = "Sporadic human infections by a novel H7N9 virus occurred over a large geographic region in China. In this study, we show that Newcastle disease virus (NDV)-vectored H7 (NDV-H7) and NDV-H5 vaccines are able to induce antibodies with high hemagglutination inhibition (HI) titers and completely protect chickens from challenge with the novel H7N9 or highly pathogenic H5N1 viruses, respectively. Notably, a baculovirus-expressed H7 protein failed to protect chickens from H7N9 virus infection.",

author = "Qinfang Liu and Ignacio Mena and Jingjiao Ma and Bhupinder Bawa and Florian Krammer and Lyoo, {Young S.} and Yuekun Lang and Igor Morozov and Mahardika, {Gusti Ngurah} and Wenjun Ma and Adolfo Garc{\'i}a-Sastre and Richt, {Juergen A.}",

note = "Publisher Copyright: {\textcopyright} 2015, American Society for Microbiology.",

year = "2015",

doi = "10.1128/JVI.00031-15",

language = "English",

volume = "89",

pages = "6994--7006",

journal = "Journal of Virology",

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publisher = "American Society for Microbiology",

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TY - JOUR

T1 - Newcastle disease virus-vectored H7 and H5 live vaccines protect chickens from challenge with H7N9 or H5N1 avian influenza viruses

AU - Liu, Qinfang

AU - Mena, Ignacio

AU - Ma, Jingjiao

AU - Bawa, Bhupinder

AU - Krammer, Florian

AU - Lyoo, Young S.

AU - Lang, Yuekun

AU - Morozov, Igor

AU - Mahardika, Gusti Ngurah

AU - Ma, Wenjun

AU - García-Sastre, Adolfo

AU - Richt, Juergen A.

PY - 2015

Y1 - 2015

N2 - Sporadic human infections by a novel H7N9 virus occurred over a large geographic region in China. In this study, we show that Newcastle disease virus (NDV)-vectored H7 (NDV-H7) and NDV-H5 vaccines are able to induce antibodies with high hemagglutination inhibition (HI) titers and completely protect chickens from challenge with the novel H7N9 or highly pathogenic H5N1 viruses, respectively. Notably, a baculovirus-expressed H7 protein failed to protect chickens from H7N9 virus infection.

AB - Sporadic human infections by a novel H7N9 virus occurred over a large geographic region in China. In this study, we show that Newcastle disease virus (NDV)-vectored H7 (NDV-H7) and NDV-H5 vaccines are able to induce antibodies with high hemagglutination inhibition (HI) titers and completely protect chickens from challenge with the novel H7N9 or highly pathogenic H5N1 viruses, respectively. Notably, a baculovirus-expressed H7 protein failed to protect chickens from H7N9 virus infection.

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U2 - 10.1128/JVI.00031-15

DO - 10.1128/JVI.00031-15

M3 - Article

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AN - SCOPUS:84931035985

SN - 0022-538X

VL - 89

SP - 6994

EP - 7006

JO - Journal of Virology

JF - Journal of Virology

IS - 14

ER -

Newcastle disease virus-vectored H7 and H5 live vaccines protect chickens from challenge with H7N9 or H5N1 avian influenza viruses

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