Newcastle disease virus-vectored H7 and H5 live vaccines protect chickens from challenge with H7N9 or H5N1 avian influenza viruses

Qinfang Liu, Ignacio Mena, Jingjiao Ma, Bhupinder Bawa, Florian Krammer, Young S. Lyoo, Yuekun Lang, Igor Morozov, Gusti Ngurah Mahardika, Wenjun Ma, Adolfo García-Sastre, Juergen A. Richt

Research output: Contribution to journalArticlepeer-review

51 Scopus citations

Abstract

Sporadic human infections by a novel H7N9 virus occurred over a large geographic region in China. In this study, we show that Newcastle disease virus (NDV)-vectored H7 (NDV-H7) and NDV-H5 vaccines are able to induce antibodies with high hemagglutination inhibition (HI) titers and completely protect chickens from challenge with the novel H7N9 or highly pathogenic H5N1 viruses, respectively. Notably, a baculovirus-expressed H7 protein failed to protect chickens from H7N9 virus infection.

Original languageEnglish
Pages (from-to)6994-7006
Number of pages13
JournalJournal of Virology
Volume89
Issue number14
DOIs
StatePublished - 2015

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