New Views of Old Proteins: Clarifying the Enigmatic Proteome

Kristin E. Burnum-Johnson, Thomas P. Conrads, Richard R. Drake, Amy E. Herr, Ravi Iyengar, Ryan T. Kelly, Emma Lundberg, Michael J. MacCoss, Alexandra Naba, Garry P. Nolan, Pavel A. Pevzner, Karin D. Rodland, Salvatore Sechi, Nikolai Slavov, Jeffrey M. Spraggins, Jennifer E. Van Eyk, Marc Vidal, Christine Vogel, David R. Walt, Neil L. Kelleher

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

All human diseases involve proteins, yet our current tools to characterize and quantify them are limited. To better elucidate proteins across space, time, and molecular composition, we provide a >10 years of projection for technologies to meet the challenges that protein biology presents. With a broad perspective, we discuss grand opportunities to transition the science of proteomics into a more propulsive enterprise. Extrapolating recent trends, we describe a next generation of approaches to define, quantify, and visualize the multiple dimensions of the proteome, thereby transforming our understanding and interactions with human disease in the coming decade.

Original languageEnglish
Article number100254
JournalMolecular and Cellular Proteomics
Volume21
Issue number7
DOIs
StatePublished - Jul 2022

Fingerprint

Dive into the research topics of 'New Views of Old Proteins: Clarifying the Enigmatic Proteome'. Together they form a unique fingerprint.

Cite this