New synthesis of L-m-sarcolysin and tritiated sarcolysin

Imre Weisz; John Roboz; J. George Bekesi

doi:10.1016/0960-894X(95)00517-8

New synthesis of L-m-sarcolysin and tritiated sarcolysin

Imre Weisz, John Roboz, J. George Bekesi

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3 Scopus citations

Abstract

L-m-sarcolysin, L-3-[bis(2-chloroethyl) amino]-L-phenylalanine was synthesized by converting 3-nitro-L-tyrosine to L-N-acetyl-3-aminophenyl-alanine Me-ester which was hydroxyethylated and converted into the N-mustard with mesyl chloride and LiCl; the title compound was obtained by hydrolysis of the protecting groups. The tritiated compound was specifically labeled on the benzyl group.

Original language	English
Pages (from-to)	2985-2988
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	5
Issue number	24
DOIs	https://doi.org/10.1016/0960-894X(95)00517-8
State	Published - 21 Dec 1995

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@article{3d2ab80726a7402f89dd2e98ea799a34,

title = "New synthesis of L-m-sarcolysin and tritiated sarcolysin",

abstract = "L-m-sarcolysin, L-3-[bis(2-chloroethyl) amino]-L-phenylalanine was synthesized by converting 3-nitro-L-tyrosine to L-N-acetyl-3-aminophenyl-alanine Me-ester which was hydroxyethylated and converted into the N-mustard with mesyl chloride and LiCl; the title compound was obtained by hydrolysis of the protecting groups. The tritiated compound was specifically labeled on the benzyl group.",

author = "Imre Weisz and John Roboz and Bekesi, \{J. George\}",

note = "Funding Information: Acknowledgement. Supported by the T.J. Martell Foundation for Cancer, Leukemia and AIDS Research. Thanks are due to Dr. Laszlo Sarkozi, Director of the Chemistry Department, for all of his support.",

year = "1995",

month = dec,

day = "21",

doi = "10.1016/0960-894X(95)00517-8",

language = "English",

volume = "5",

pages = "2985--2988",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd.",

number = "24",

}

TY - JOUR

T1 - New synthesis of L-m-sarcolysin and tritiated sarcolysin

AU - Weisz, Imre

AU - Roboz, John

AU - Bekesi, J. George

N1 - Funding Information: Acknowledgement. Supported by the T.J. Martell Foundation for Cancer, Leukemia and AIDS Research. Thanks are due to Dr. Laszlo Sarkozi, Director of the Chemistry Department, for all of his support.

PY - 1995/12/21

Y1 - 1995/12/21

N2 - L-m-sarcolysin, L-3-[bis(2-chloroethyl) amino]-L-phenylalanine was synthesized by converting 3-nitro-L-tyrosine to L-N-acetyl-3-aminophenyl-alanine Me-ester which was hydroxyethylated and converted into the N-mustard with mesyl chloride and LiCl; the title compound was obtained by hydrolysis of the protecting groups. The tritiated compound was specifically labeled on the benzyl group.

AB - L-m-sarcolysin, L-3-[bis(2-chloroethyl) amino]-L-phenylalanine was synthesized by converting 3-nitro-L-tyrosine to L-N-acetyl-3-aminophenyl-alanine Me-ester which was hydroxyethylated and converted into the N-mustard with mesyl chloride and LiCl; the title compound was obtained by hydrolysis of the protecting groups. The tritiated compound was specifically labeled on the benzyl group.

UR - https://www.scopus.com/pages/publications/0028789617

U2 - 10.1016/0960-894X(95)00517-8

DO - 10.1016/0960-894X(95)00517-8

M3 - Article

AN - SCOPUS:0028789617

SN - 0960-894X

VL - 5

SP - 2985

EP - 2988

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 24

ER -

New synthesis of L-m-sarcolysin and tritiated sarcolysin

Abstract

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