New strategies to deliver anticancer drugs to brain tumors

Valentino Laquintana; Adriana Trapani; Nunzio Denora; Fan Wang; James M. Gallo; Giuseppe Trapani

doi:10.1517/17425240903167942

New strategies to deliver anticancer drugs to brain tumors

Valentino Laquintana, Adriana Trapani, Nunzio Denora, Fan Wang, James M. Gallo, Giuseppe Trapani

Research output: Contribution to journal › Review article › peer-review

188 Scopus citations

Abstract

Background: Malignant brain tumors are among the most challenging to treat and at present there are no uniformly successful treatment strategies. Standard treatment regimens consist of maximal surgical resection followed by radiotherapy and chemotherapy. The limited survival advantage attributed to chemotherapy is partially due to low CNS penetration of antineo-plastic agents across the blood-brain barrier (BBB). Objective: The objective of this paper is to review recent approaches to delivering anticancer drugs into primary brain tumors. Methods: Both preclinical and clinical strategies to circumvent the BBB are considered that include chemical modification and colloidal carriers. Conclusion: Analysis of the available data indicates that new approaches may be useful for CNS delivery, yet an appreciation of pharmacokinetic issues and improved knowledge of tumor biology will be needed to affect significantly drug delivery to the target site.

Original language	English
Pages (from-to)	1017-1032
Number of pages	16
Journal	Expert Opinion on Drug Delivery
Volume	6
Issue number	10
DOIs	https://doi.org/10.1517/17425240903167942
State	Published - Oct 2009
Externally published	Yes

Keywords

Blood-brain barrier
Drug delivery strategies
Glioma
Nanocarriers
Targeted therapy

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10.1517/17425240903167942

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title = "New strategies to deliver anticancer drugs to brain tumors",

abstract = "Background: Malignant brain tumors are among the most challenging to treat and at present there are no uniformly successful treatment strategies. Standard treatment regimens consist of maximal surgical resection followed by radiotherapy and chemotherapy. The limited survival advantage attributed to chemotherapy is partially due to low CNS penetration of antineo-plastic agents across the blood-brain barrier (BBB). Objective: The objective of this paper is to review recent approaches to delivering anticancer drugs into primary brain tumors. Methods: Both preclinical and clinical strategies to circumvent the BBB are considered that include chemical modification and colloidal carriers. Conclusion: Analysis of the available data indicates that new approaches may be useful for CNS delivery, yet an appreciation of pharmacokinetic issues and improved knowledge of tumor biology will be needed to affect significantly drug delivery to the target site.",

keywords = "Blood-brain barrier, Drug delivery strategies, Glioma, Nanocarriers, Targeted therapy",

author = "Valentino Laquintana and Adriana Trapani and Nunzio Denora and Fan Wang and Gallo, {James M.} and Giuseppe Trapani",

note = "Funding Information: This work was supported by grants from Universit{\`a} degli Studi di Bari {\textquoteleft}Fondi d{\textquoteright}Ateneo 2008{\textquoteright} to G Trapani and in part by NIH grants (CA072937 and CA127963) awarded to JM Gallo.",

year = "2009",

month = oct,

doi = "10.1517/17425240903167942",

language = "English",

volume = "6",

pages = "1017--1032",

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number = "10",

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TY - JOUR

T1 - New strategies to deliver anticancer drugs to brain tumors

AU - Laquintana, Valentino

AU - Trapani, Adriana

AU - Denora, Nunzio

AU - Wang, Fan

AU - Gallo, James M.

AU - Trapani, Giuseppe

N1 - Funding Information: This work was supported by grants from Università degli Studi di Bari ‘Fondi d’Ateneo 2008’ to G Trapani and in part by NIH grants (CA072937 and CA127963) awarded to JM Gallo.

PY - 2009/10

Y1 - 2009/10

N2 - Background: Malignant brain tumors are among the most challenging to treat and at present there are no uniformly successful treatment strategies. Standard treatment regimens consist of maximal surgical resection followed by radiotherapy and chemotherapy. The limited survival advantage attributed to chemotherapy is partially due to low CNS penetration of antineo-plastic agents across the blood-brain barrier (BBB). Objective: The objective of this paper is to review recent approaches to delivering anticancer drugs into primary brain tumors. Methods: Both preclinical and clinical strategies to circumvent the BBB are considered that include chemical modification and colloidal carriers. Conclusion: Analysis of the available data indicates that new approaches may be useful for CNS delivery, yet an appreciation of pharmacokinetic issues and improved knowledge of tumor biology will be needed to affect significantly drug delivery to the target site.

AB - Background: Malignant brain tumors are among the most challenging to treat and at present there are no uniformly successful treatment strategies. Standard treatment regimens consist of maximal surgical resection followed by radiotherapy and chemotherapy. The limited survival advantage attributed to chemotherapy is partially due to low CNS penetration of antineo-plastic agents across the blood-brain barrier (BBB). Objective: The objective of this paper is to review recent approaches to delivering anticancer drugs into primary brain tumors. Methods: Both preclinical and clinical strategies to circumvent the BBB are considered that include chemical modification and colloidal carriers. Conclusion: Analysis of the available data indicates that new approaches may be useful for CNS delivery, yet an appreciation of pharmacokinetic issues and improved knowledge of tumor biology will be needed to affect significantly drug delivery to the target site.

KW - Blood-brain barrier

KW - Drug delivery strategies

KW - Glioma

KW - Nanocarriers

KW - Targeted therapy

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M3 - Review article

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AN - SCOPUS:70349408777

SN - 1742-5247

VL - 6

SP - 1017

EP - 1032

JO - Expert Opinion on Drug Delivery

JF - Expert Opinion on Drug Delivery

IS - 10

ER -

New strategies to deliver anticancer drugs to brain tumors

Abstract

Keywords

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