New Medical and Injectable Treatments for LUTS/BPH - Anticholinergics, PDE-5, and Botox

Steven J. Weissbart; Karl Coutinho; Dean S. Elterman; Bilal Chughtai

doi:10.1007/s11884-014-0227-x

New Medical and Injectable Treatments for LUTS/BPH - Anticholinergics, PDE-5, and Botox

Steven J. Weissbart, Karl Coutinho, Dean S. Elterman, Bilal Chughtai

Icahn School of Medicine at Mount Sinai

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Although alpha-blockers, 5-alpha-reductase inhibitors and prostatectomy are clearly efficacious treatment options for men with LUTS/BPH, these therapies are less than perfect. This has led to the investigation of new treatment options for men with LUTS/BPH. Three of these new treatment options include anticholinergics, phosphodiesterase-5-inhibitors (PDE5I), and botulinum toxin A (BoNT-A). Of these, anticholinergics and PDE5I have demonstrated a clear efficacy in appropriately selected patients. On the other hand, despite initial promising data, recent studies have not supported a clear efficacy with intraprostatic BoNT-A. The literature on anticholinergics, PDE5I, and BoNT-A is reviewed. Areas for future research within the field are then presented along with guidelines for prescribing these therapies.

Original language	English
Pages (from-to)	114-121
Number of pages	8
Journal	Current Bladder Dysfunction Reports
Volume	9
Issue number	2
DOIs	https://doi.org/10.1007/s11884-014-0227-x
State	Published - Jun 2014

Keywords

5-alpha-reductase inhibitors
Adrenergic alpha-antagonists
BPH
Benign prostatic hyperplasia
Cholinergic antagonists
Combined modality therapy
LUTS
Lower urinary tract symptoms
OnabotulinumtoxinA
Phosphodiesterase inhibitors
Prostatectomy
Prostatic diseases
Urinary retention
Urinary tract
Voiding dysfunction

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10.1007/s11884-014-0227-x

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title = "New Medical and Injectable Treatments for LUTS/BPH - Anticholinergics, PDE-5, and Botox",

abstract = "Although alpha-blockers, 5-alpha-reductase inhibitors and prostatectomy are clearly efficacious treatment options for men with LUTS/BPH, these therapies are less than perfect. This has led to the investigation of new treatment options for men with LUTS/BPH. Three of these new treatment options include anticholinergics, phosphodiesterase-5-inhibitors (PDE5I), and botulinum toxin A (BoNT-A). Of these, anticholinergics and PDE5I have demonstrated a clear efficacy in appropriately selected patients. On the other hand, despite initial promising data, recent studies have not supported a clear efficacy with intraprostatic BoNT-A. The literature on anticholinergics, PDE5I, and BoNT-A is reviewed. Areas for future research within the field are then presented along with guidelines for prescribing these therapies.",

keywords = "5-alpha-reductase inhibitors, Adrenergic alpha-antagonists, BPH, Benign prostatic hyperplasia, Cholinergic antagonists, Combined modality therapy, LUTS, Lower urinary tract symptoms, OnabotulinumtoxinA, Phosphodiesterase inhibitors, Prostatectomy, Prostatic diseases, Urinary retention, Urinary tract, Voiding dysfunction",

author = "Weissbart, {Steven J.} and Karl Coutinho and Elterman, {Dean S.} and Bilal Chughtai",

year = "2014",

month = jun,

doi = "10.1007/s11884-014-0227-x",

language = "English",

volume = "9",

pages = "114--121",

journal = "Current Bladder Dysfunction Reports",

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T1 - New Medical and Injectable Treatments for LUTS/BPH - Anticholinergics, PDE-5, and Botox

AU - Weissbart, Steven J.

AU - Coutinho, Karl

AU - Elterman, Dean S.

AU - Chughtai, Bilal

PY - 2014/6

Y1 - 2014/6

N2 - Although alpha-blockers, 5-alpha-reductase inhibitors and prostatectomy are clearly efficacious treatment options for men with LUTS/BPH, these therapies are less than perfect. This has led to the investigation of new treatment options for men with LUTS/BPH. Three of these new treatment options include anticholinergics, phosphodiesterase-5-inhibitors (PDE5I), and botulinum toxin A (BoNT-A). Of these, anticholinergics and PDE5I have demonstrated a clear efficacy in appropriately selected patients. On the other hand, despite initial promising data, recent studies have not supported a clear efficacy with intraprostatic BoNT-A. The literature on anticholinergics, PDE5I, and BoNT-A is reviewed. Areas for future research within the field are then presented along with guidelines for prescribing these therapies.

AB - Although alpha-blockers, 5-alpha-reductase inhibitors and prostatectomy are clearly efficacious treatment options for men with LUTS/BPH, these therapies are less than perfect. This has led to the investigation of new treatment options for men with LUTS/BPH. Three of these new treatment options include anticholinergics, phosphodiesterase-5-inhibitors (PDE5I), and botulinum toxin A (BoNT-A). Of these, anticholinergics and PDE5I have demonstrated a clear efficacy in appropriately selected patients. On the other hand, despite initial promising data, recent studies have not supported a clear efficacy with intraprostatic BoNT-A. The literature on anticholinergics, PDE5I, and BoNT-A is reviewed. Areas for future research within the field are then presented along with guidelines for prescribing these therapies.

KW - 5-alpha-reductase inhibitors

KW - Adrenergic alpha-antagonists

KW - BPH

KW - Benign prostatic hyperplasia

KW - Cholinergic antagonists

KW - Combined modality therapy

KW - LUTS

KW - Lower urinary tract symptoms

KW - OnabotulinumtoxinA

KW - Phosphodiesterase inhibitors

KW - Prostatectomy

KW - Prostatic diseases

KW - Urinary retention

KW - Urinary tract

KW - Voiding dysfunction

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DO - 10.1007/s11884-014-0227-x

M3 - Review article

AN - SCOPUS:84899547270

SN - 1931-7212

VL - 9

SP - 114

EP - 121

JO - Current Bladder Dysfunction Reports

JF - Current Bladder Dysfunction Reports

IS - 2

ER -

New Medical and Injectable Treatments for LUTS/BPH - Anticholinergics, PDE-5, and Botox

Abstract

Keywords

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