New insights of HLA class I association to Behçet's disease in Portuguese patients

A. Bettencourt; C. Pereira; L. Carvalho; C. Carvalho; J. V. Patto; M. Bastos; A. M. Silva; R. Barros; C. Vasconcelos; P. Paiva; L. Costa; P. P. Costa; D. Mendonça; J. Correia; B. M. Silva

doi:10.1111/j.1399-0039.2008.01087.x

New insights of HLA class I association to Behçet's disease in Portuguese patients

A. Bettencourt, C. Pereira, L. Carvalho, C. Carvalho, J. V. Patto, M. Bastos, A. M. Silva, R. Barros, C. Vasconcelos, P. Paiva, L. Costa, P. P. Costa, D. Mendonça, J. Correia, B. M. Silva

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Human leukocyte antigen (HLA)-B*51 is a well-known genetic factor associated with Behçet's disease (BD). To analyse the influence of HLA-B*51 and other HLA class I alleles in BD susceptibility in a Portuguese population and its association with disease severity, we studied 78 BD patients and 208 healthy controls. The patients were classified into two severity groups as described by Gul et al. As expected, a higher frequency of HLA-B*51 was found. The frequency of HLA-Cw*16 alleles was significantly higher in patients. Regarding severity, HLA-B*27 frequency was higher in the severe group compared with controls and with the mild group. Thus, HLA-B*51 and HLA-Cw*16 seem to confer susceptibility to BD in this patients. HLA-B*27 may be important as a prognostic factor.

Original language	English
Pages (from-to)	379-382
Number of pages	4
Journal	Tissue Antigens
Volume	72
Issue number	4
DOIs	https://doi.org/10.1111/j.1399-0039.2008.01087.x
State	Published - Oct 2008
Externally published	Yes

Keywords

Behçet's disease
Disease severity
Human leukocyte antigen class I
Portugal

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10.1111/j.1399-0039.2008.01087.x

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Bettencourt, A., Pereira, C., Carvalho, L., Carvalho, C., Patto, J. V., Bastos, M., Silva, A. M., Barros, R., Vasconcelos, C., Paiva, P., Costa, L., Costa, P. P., Mendonça, D., Correia, J., & Silva, B. M. (2008). New insights of HLA class I association to Behçet's disease in Portuguese patients. Tissue Antigens, 72(4), 379-382. https://doi.org/10.1111/j.1399-0039.2008.01087.x

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title = "New insights of HLA class I association to Beh{\c c}et's disease in Portuguese patients",

abstract = "Human leukocyte antigen (HLA)-B*51 is a well-known genetic factor associated with Beh{\c c}et's disease (BD). To analyse the influence of HLA-B*51 and other HLA class I alleles in BD susceptibility in a Portuguese population and its association with disease severity, we studied 78 BD patients and 208 healthy controls. The patients were classified into two severity groups as described by Gul et al. As expected, a higher frequency of HLA-B*51 was found. The frequency of HLA-Cw*16 alleles was significantly higher in patients. Regarding severity, HLA-B*27 frequency was higher in the severe group compared with controls and with the mild group. Thus, HLA-B*51 and HLA-Cw*16 seem to confer susceptibility to BD in this patients. HLA-B*27 may be important as a prognostic factor.",

keywords = "Beh{\c c}et's disease, Disease severity, Human leukocyte antigen class I, Portugal",

author = "A. Bettencourt and C. Pereira and L. Carvalho and C. Carvalho and Patto, {J. V.} and M. Bastos and Silva, {A. M.} and R. Barros and C. Vasconcelos and P. Paiva and L. Costa and Costa, {P. P.} and D. Mendon{\c c}a and J. Correia and Silva, {B. M.}",

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AU - Bettencourt, A.

AU - Pereira, C.

AU - Carvalho, L.

AU - Carvalho, C.

AU - Patto, J. V.

AU - Bastos, M.

AU - Silva, A. M.

AU - Barros, R.

AU - Vasconcelos, C.

AU - Paiva, P.

AU - Costa, L.

AU - Costa, P. P.

AU - Mendonça, D.

AU - Correia, J.

AU - Silva, B. M.

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N2 - Human leukocyte antigen (HLA)-B*51 is a well-known genetic factor associated with Behçet's disease (BD). To analyse the influence of HLA-B*51 and other HLA class I alleles in BD susceptibility in a Portuguese population and its association with disease severity, we studied 78 BD patients and 208 healthy controls. The patients were classified into two severity groups as described by Gul et al. As expected, a higher frequency of HLA-B*51 was found. The frequency of HLA-Cw*16 alleles was significantly higher in patients. Regarding severity, HLA-B*27 frequency was higher in the severe group compared with controls and with the mild group. Thus, HLA-B*51 and HLA-Cw*16 seem to confer susceptibility to BD in this patients. HLA-B*27 may be important as a prognostic factor.

AB - Human leukocyte antigen (HLA)-B*51 is a well-known genetic factor associated with Behçet's disease (BD). To analyse the influence of HLA-B*51 and other HLA class I alleles in BD susceptibility in a Portuguese population and its association with disease severity, we studied 78 BD patients and 208 healthy controls. The patients were classified into two severity groups as described by Gul et al. As expected, a higher frequency of HLA-B*51 was found. The frequency of HLA-Cw*16 alleles was significantly higher in patients. Regarding severity, HLA-B*27 frequency was higher in the severe group compared with controls and with the mild group. Thus, HLA-B*51 and HLA-Cw*16 seem to confer susceptibility to BD in this patients. HLA-B*27 may be important as a prognostic factor.

KW - Behçet's disease

KW - Disease severity

KW - Human leukocyte antigen class I

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New insights of HLA class I association to Behçet's disease in Portuguese patients

Abstract

Keywords

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