New Insights into Multiple Sclerosis Clinical Course from the Topographical Model and Functional Reserve

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations

Abstract

Clinical course in multiple sclerosis (MS) is difficult to predict on group and individual levels. We discuss the topographical model of MS as a new approach to characterizing the clinical course, with the potential to personalize disability progression based on each individual patient's pattern of disease burden (eg, lesion location) and reserve. The dynamic clinical threshold depicted in this visual model may help clinicians to educate patients about clinical phenotype and disease burden, and foster an understanding of the difference between relapses and pseudoexacerbations. There is an emphasis on building reserve against cognitive and physical decline, encouraging agency among patients.

Original languageEnglish
Pages (from-to)13-25
Number of pages13
JournalNeurologic Clinics
Volume36
Issue number1
DOIs
StatePublished - Feb 2018

Keywords

  • Clinical course
  • Multiple sclerosis
  • Prognosis
  • Reserve
  • Topographical model

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