TY - JOUR
T1 - New insights into common variable immunodeficiency
AU - Sneller, Michael C.
AU - Strober, Warren
AU - Eisenstein, Eli
AU - Jaffe, Jonathan S.
AU - Cunningham-Rundles, Charlotte
PY - 1993/5/1
Y1 - 1993/5/1
N2 - Common variable immunodeficiency (CVI) is a heterogenous immunodeficiency syndrome characterized by hypogammaglobulinemia, recurrent bacterial infections, and various immunologic abnormalities. In addition to recurrent infections, patients with this syndrome also have an increased incidence of autoimmune disease and malignancy. Because the spectrum of associated diseases is broad, patients with CVI are seen by various medical specialists. This review discusses the pathogenesis, clinical manifestations, diagnosis, and treatment of CVI.
AB - Common variable immunodeficiency (CVI) is a heterogenous immunodeficiency syndrome characterized by hypogammaglobulinemia, recurrent bacterial infections, and various immunologic abnormalities. In addition to recurrent infections, patients with this syndrome also have an increased incidence of autoimmune disease and malignancy. Because the spectrum of associated diseases is broad, patients with CVI are seen by various medical specialists. This review discusses the pathogenesis, clinical manifestations, diagnosis, and treatment of CVI.
UR - http://www.scopus.com/inward/record.url?scp=0027602669&partnerID=8YFLogxK
M3 - Article
C2 - 8460860
AN - SCOPUS:0027602669
SN - 0003-4819
VL - 118
SP - 720
EP - 730
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
IS - 9
ER -