New insights into basophil heterogeneity

Landon K. Oetjen; Mario Noti; Brian S. Kim

doi:10.1007/s00281-016-0567-z

New insights into basophil heterogeneity

Landon K. Oetjen
, Mario Noti
, Brian S. Kim

Research output: Contribution to journal › Review article › peer-review

34 Scopus citations

Abstract

Basophils have become increasingly recognized as important innate immune cells that mediate antihelminth immunity and barrier inflammation. Recent discoveries have uncovered previously unrecognized heterogeneity in basophil populations. However, how diversity in basophil regulation and function impacts human disease remains poorly defined. The goal of the present review is to highlight how new insights into basophil heterogeneity can help us to better understand disease pathogenesis and inform the development of new therapeutics.

Original language	English
Pages (from-to)	549-561
Number of pages	13
Journal	Seminars in Immunopathology
Volume	38
Issue number	5
DOIs	https://doi.org/10.1007/s00281-016-0567-z
State	Published - 1 Sep 2016
Externally published	Yes

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title = "New insights into basophil heterogeneity",

abstract = "Basophils have become increasingly recognized as important innate immune cells that mediate antihelminth immunity and barrier inflammation. Recent discoveries have uncovered previously unrecognized heterogeneity in basophil populations. However, how diversity in basophil regulation and function impacts human disease remains poorly defined. The goal of the present review is to highlight how new insights into basophil heterogeneity can help us to better understand disease pathogenesis and inform the development of new therapeutics.",

author = "Oetjen, \{Landon K.\} and Mario Noti and Kim, \{Brian S.\}",

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AU - Oetjen, Landon K.

AU - Noti, Mario

AU - Kim, Brian S.

PY - 2016/9/1

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N2 - Basophils have become increasingly recognized as important innate immune cells that mediate antihelminth immunity and barrier inflammation. Recent discoveries have uncovered previously unrecognized heterogeneity in basophil populations. However, how diversity in basophil regulation and function impacts human disease remains poorly defined. The goal of the present review is to highlight how new insights into basophil heterogeneity can help us to better understand disease pathogenesis and inform the development of new therapeutics.

AB - Basophils have become increasingly recognized as important innate immune cells that mediate antihelminth immunity and barrier inflammation. Recent discoveries have uncovered previously unrecognized heterogeneity in basophil populations. However, how diversity in basophil regulation and function impacts human disease remains poorly defined. The goal of the present review is to highlight how new insights into basophil heterogeneity can help us to better understand disease pathogenesis and inform the development of new therapeutics.

UR - https://www.scopus.com/pages/publications/84968542307

U2 - 10.1007/s00281-016-0567-z

DO - 10.1007/s00281-016-0567-z

M3 - Review article

C2 - 27178409

AN - SCOPUS:84968542307

SN - 1863-2297

VL - 38

SP - 549

EP - 561

JO - Seminars in Immunopathology

JF - Seminars in Immunopathology

IS - 5

ER -

New insights into basophil heterogeneity

Abstract

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