New directions for frontotemporal dementia drug discovery

John Q. Trojanowski, Karen Duff, Howard Fillit, Walter Koroshetz, Jeff Kuret, Diane Murphy, Larry Refolo

Research output: Contribution to journalEditorial

26 Scopus citations


This report summarizes the recommendations of the Frontotemporal Dementia (FTD) Working Group on FTD Drug Discovery that was part of an international FTD Workshop held on January 18 and 19, 2007, in Miami, Florida. The workshop was sponsored by the National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute on Aging (NIA) of the National Institutes of Health (NIH) and the Association for Frontotemporal Dementia (AFTD) with the express purpose of defining opportunities to improve the diagnosis and treatment of patients affected by a neurodegenerative disorder classified as one of the many variants of FTD. The recognition that almost all forms of FTD are due to TDP-43 proteinopathies and tauopathies creates new opportunities for FTD drug discovery targeting pathways of TDP-43 and tau-mediated neurodegeneration.

Original languageEnglish
Pages (from-to)89-93
Number of pages5
JournalAlzheimer's and Dementia
Issue number2
StatePublished - Mar 2008
Externally publishedYes


  • Frontotemporal dementia
  • Neurodegeneration
  • Prevention
  • TDP-43
  • Tau
  • Therapy


Dive into the research topics of 'New directions for frontotemporal dementia drug discovery'. Together they form a unique fingerprint.

Cite this