New developments of biofluid-based biomarkers for routine diagnosis and disease trajectories in frontotemporal dementia

Marta del Campo, Henrik Zetterberg, Sam Gandy, Chiadi U. Onyike, Fabricio Oliveira, Chi Udeh-Momoh, Alberto Lleó, Charlotte E. Teunissen, Yolande Pijnenburg

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations

Abstract

Frontotemporal dementia (FTD) covers a spectrum of neurodegenerative disorders with different phenotypes, genetic backgrounds, and pathological states. Its clinicopathological diversity challenges the diagnostic process and the execution of clinical trials, calling for specific diagnostic biomarkers of pathologic FTD types. There is also a need for biomarkers that facilitate disease staging, quantification of severity, monitoring in clinics and observational studies, and for evaluation of target engagement and treatment response in clinical trials. This review discusses current FTD biofluid-based biomarker knowledge taking into account the differing applications. The limitations, knowledge gaps, and challenges for the development and implementation of such markers are also examined. Strategies to overcome these hurdles are proposed, including the technologies available, patient cohorts, and collaborative research initiatives. Access to robust and reliable biomarkers that define the exact underlying pathophysiological FTD process will meet the needs for specific diagnosis, disease quantitation, clinical monitoring, and treatment development.

Original languageEnglish
Pages (from-to)2292-2307
Number of pages16
JournalAlzheimer's and Dementia
Volume18
Issue number11
DOIs
StatePublished - Nov 2022

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