New developments in human neurocognition: Clinical, genetic, and brain imaging correlates of impulsivity and compulsivity

Naomi A. Fineberg; Samuel R. Chamberlain; Anna E. Goudriaan; Dan J. Stein; Louk J.M.J. Vanderschuren; Claire M. Gillan; Sameer Shekar; Philip A.P.M. Gorwood; Valerie Voon; Sharon Morein-Zamir; Damiaan Denys; Barbara J. Sahakian; F. Gerard Moeller; Trevor W. Robbins; Marc N. Potenza

doi:10.1017/S1092852913000801

New developments in human neurocognition: Clinical, genetic, and brain imaging correlates of impulsivity and compulsivity

Naomi A. Fineberg, Samuel R. Chamberlain, Anna E. Goudriaan, Dan J. Stein, Louk J.M.J. Vanderschuren, Claire M. Gillan, Sameer Shekar, Philip A.P.M. Gorwood, Valerie Voon, Sharon Morein-Zamir, Damiaan Denys, Barbara J. Sahakian, F. Gerard Moeller, Trevor W. Robbins, Marc N. Potenza

Research output: Contribution to journal › Review article › peer-review

338 Scopus citations

Abstract

Impulsivity and compulsivity represent useful conceptualizations that involve dissociable cognitive functions, which are mediated by neuroanatomically and neurochemically distinct components of cortico-subcortical circuitry. The constructs were historically viewed as diametrically opposed, with impulsivity being associated with risk-seeking and compulsivity with harm-avoidance. However, they are increasingly recognized to be linked by shared neuropsychological mechanisms involving dysfunctional inhibition of thoughts and behaviors. In this article, we selectively review new developments in the investigation of the neurocognition of impulsivity and compulsivity in humans, in order to advance our understanding of the pathophysiology of impulsive, compulsive, and addictive disorders and indicate new directions for research.

Original language	English
Pages (from-to)	69-89
Number of pages	21
Journal	CNS Spectrums
Volume	19
Issue number	1
DOIs	https://doi.org/10.1017/S1092852913000801
State	Published - Feb 2014
Externally published	Yes

Keywords

addictive
compulsive
impulsive
neurocognition

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Fineberg, N. A., Chamberlain, S. R., Goudriaan, A. E., Stein, D. J., Vanderschuren, L. J. M. J., Gillan, C. M., Shekar, S., Gorwood, P. A. P. M., Voon, V., Morein-Zamir, S., Denys, D., Sahakian, B. J., Moeller, F. G., Robbins, T. W., & Potenza, M. N. (2014). New developments in human neurocognition: Clinical, genetic, and brain imaging correlates of impulsivity and compulsivity. CNS Spectrums, 19(1), 69-89. https://doi.org/10.1017/S1092852913000801

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title = "New developments in human neurocognition: Clinical, genetic, and brain imaging correlates of impulsivity and compulsivity",

abstract = "Impulsivity and compulsivity represent useful conceptualizations that involve dissociable cognitive functions, which are mediated by neuroanatomically and neurochemically distinct components of cortico-subcortical circuitry. The constructs were historically viewed as diametrically opposed, with impulsivity being associated with risk-seeking and compulsivity with harm-avoidance. However, they are increasingly recognized to be linked by shared neuropsychological mechanisms involving dysfunctional inhibition of thoughts and behaviors. In this article, we selectively review new developments in the investigation of the neurocognition of impulsivity and compulsivity in humans, in order to advance our understanding of the pathophysiology of impulsive, compulsive, and addictive disorders and indicate new directions for research.",

keywords = "addictive, compulsive, impulsive, neurocognition",

author = "Fineberg, {Naomi A.} and Chamberlain, {Samuel R.} and Goudriaan, {Anna E.} and Stein, {Dan J.} and Vanderschuren, {Louk J.M.J.} and Gillan, {Claire M.} and Sameer Shekar and Gorwood, {Philip A.P.M.} and Valerie Voon and Sharon Morein-Zamir and Damiaan Denys and Sahakian, {Barbara J.} and Moeller, {F. Gerard} and Robbins, {Trevor W.} and Potenza, {Marc N.}",

year = "2014",

month = feb,

doi = "10.1017/S1092852913000801",

language = "English",

volume = "19",

pages = "69--89",

journal = "CNS Spectrums",

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publisher = "Cambridge University Press",

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Fineberg, NA, Chamberlain, SR, Goudriaan, AE, Stein, DJ, Vanderschuren, LJMJ, Gillan, CM, Shekar, S, Gorwood, PAPM, Voon, V, Morein-Zamir, S, Denys, D, Sahakian, BJ, Moeller, FG, Robbins, TW & Potenza, MN 2014, 'New developments in human neurocognition: Clinical, genetic, and brain imaging correlates of impulsivity and compulsivity', CNS Spectrums, vol. 19, no. 1, pp. 69-89. https://doi.org/10.1017/S1092852913000801

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AU - Stein, Dan J.

AU - Vanderschuren, Louk J.M.J.

AU - Gillan, Claire M.

AU - Shekar, Sameer

AU - Gorwood, Philip A.P.M.

AU - Voon, Valerie

AU - Morein-Zamir, Sharon

AU - Denys, Damiaan

AU - Sahakian, Barbara J.

AU - Moeller, F. Gerard

AU - Robbins, Trevor W.

AU - Potenza, Marc N.

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AB - Impulsivity and compulsivity represent useful conceptualizations that involve dissociable cognitive functions, which are mediated by neuroanatomically and neurochemically distinct components of cortico-subcortical circuitry. The constructs were historically viewed as diametrically opposed, with impulsivity being associated with risk-seeking and compulsivity with harm-avoidance. However, they are increasingly recognized to be linked by shared neuropsychological mechanisms involving dysfunctional inhibition of thoughts and behaviors. In this article, we selectively review new developments in the investigation of the neurocognition of impulsivity and compulsivity in humans, in order to advance our understanding of the pathophysiology of impulsive, compulsive, and addictive disorders and indicate new directions for research.

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New developments in human neurocognition: Clinical, genetic, and brain imaging correlates of impulsivity and compulsivity

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