Neutrophil-to-lymphocyte ratio as a prognostic indicator for overall and cancer-specific survival in squamous cell carcinoma of the head and neck

Rocco M. Ferrandino; Scott Roof; Jonathan Garneau; Yarah Haidar; Susan E. Bates; Yeun Hee A. Park; Joshua M. Bauml; Eric M. Genden; Brett Miles; Keith Sigel

doi:10.1002/hed.26329

Neutrophil-to-lymphocyte ratio as a prognostic indicator for overall and cancer-specific survival in squamous cell carcinoma of the head and neck

Rocco M. Ferrandino, Scott Roof, Jonathan Garneau, Yarah Haidar, Susan E. Bates, Yeun Hee A. Park, Joshua M. Bauml, Eric M. Genden, Brett Miles, Keith Sigel

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Background: Neutrophil-to-lymphocyte ratio (NLR) is a biomarker that is correlated with systemic inflammation and poor prognosis in solid tumors. We investigated the value of NLR in predicting survival in a large population of head and neck cancer patients in the United States. Methods: We performed a retrospective cohort study of Veterans Affairs patients with head and neck squamous cell carcinoma (HNSCC) diagnosed between January 2000 and December 2017. We compared 5-year overall survival and cancer-specific survival for different NLR tertiles using cox proportional hazards modeling with adjustment for covariates. Results: The primary cohort consisted of 14 644 subjects of which 99% were male. Relative to patients with NLRs in the lower tertile, patients with NLRs in the top tertile had an 71% increased hazard of all-cause mortality (P <.001) and 44% increased hazard of cancer-specific mortality (P <.001) at 5 years. Conclusions: Elevated NLR in HNSCC confers a poor prognosis.

Original language	English
Pages (from-to)	2830-2840
Number of pages	11
Journal	Head and Neck
Volume	42
Issue number	10
DOIs	https://doi.org/10.1002/hed.26329
State	Published - 1 Oct 2020

Keywords

head and neck squamous cell carcinoma
laryngeal carcinoma
neutrophil-to-lymphocyte ratio
oral cavity carcinoma
oropharyngeal carcinoma

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@article{a278f522cd8f4165a7ceca4810a5fe66,

title = "Neutrophil-to-lymphocyte ratio as a prognostic indicator for overall and cancer-specific survival in squamous cell carcinoma of the head and neck",

abstract = "Background: Neutrophil-to-lymphocyte ratio (NLR) is a biomarker that is correlated with systemic inflammation and poor prognosis in solid tumors. We investigated the value of NLR in predicting survival in a large population of head and neck cancer patients in the United States. Methods: We performed a retrospective cohort study of Veterans Affairs patients with head and neck squamous cell carcinoma (HNSCC) diagnosed between January 2000 and December 2017. We compared 5-year overall survival and cancer-specific survival for different NLR tertiles using cox proportional hazards modeling with adjustment for covariates. Results: The primary cohort consisted of 14 644 subjects of which 99% were male. Relative to patients with NLRs in the lower tertile, patients with NLRs in the top tertile had an 71% increased hazard of all-cause mortality (P <.001) and 44% increased hazard of cancer-specific mortality (P <.001) at 5 years. Conclusions: Elevated NLR in HNSCC confers a poor prognosis.",

keywords = "head and neck squamous cell carcinoma, laryngeal carcinoma, neutrophil-to-lymphocyte ratio, oral cavity carcinoma, oropharyngeal carcinoma",

author = "Ferrandino, {Rocco M.} and Scott Roof and Jonathan Garneau and Yarah Haidar and Bates, {Susan E.} and Park, {Yeun Hee A.} and Bauml, {Joshua M.} and Genden, {Eric M.} and Brett Miles and Keith Sigel",

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year = "2020",

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doi = "10.1002/hed.26329",

language = "English",

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T1 - Neutrophil-to-lymphocyte ratio as a prognostic indicator for overall and cancer-specific survival in squamous cell carcinoma of the head and neck

AU - Ferrandino, Rocco M.

AU - Roof, Scott

AU - Garneau, Jonathan

AU - Haidar, Yarah

AU - Bates, Susan E.

AU - Park, Yeun Hee A.

AU - Bauml, Joshua M.

AU - Genden, Eric M.

AU - Miles, Brett

AU - Sigel, Keith

PY - 2020/10/1

Y1 - 2020/10/1

N2 - Background: Neutrophil-to-lymphocyte ratio (NLR) is a biomarker that is correlated with systemic inflammation and poor prognosis in solid tumors. We investigated the value of NLR in predicting survival in a large population of head and neck cancer patients in the United States. Methods: We performed a retrospective cohort study of Veterans Affairs patients with head and neck squamous cell carcinoma (HNSCC) diagnosed between January 2000 and December 2017. We compared 5-year overall survival and cancer-specific survival for different NLR tertiles using cox proportional hazards modeling with adjustment for covariates. Results: The primary cohort consisted of 14 644 subjects of which 99% were male. Relative to patients with NLRs in the lower tertile, patients with NLRs in the top tertile had an 71% increased hazard of all-cause mortality (P <.001) and 44% increased hazard of cancer-specific mortality (P <.001) at 5 years. Conclusions: Elevated NLR in HNSCC confers a poor prognosis.

AB - Background: Neutrophil-to-lymphocyte ratio (NLR) is a biomarker that is correlated with systemic inflammation and poor prognosis in solid tumors. We investigated the value of NLR in predicting survival in a large population of head and neck cancer patients in the United States. Methods: We performed a retrospective cohort study of Veterans Affairs patients with head and neck squamous cell carcinoma (HNSCC) diagnosed between January 2000 and December 2017. We compared 5-year overall survival and cancer-specific survival for different NLR tertiles using cox proportional hazards modeling with adjustment for covariates. Results: The primary cohort consisted of 14 644 subjects of which 99% were male. Relative to patients with NLRs in the lower tertile, patients with NLRs in the top tertile had an 71% increased hazard of all-cause mortality (P <.001) and 44% increased hazard of cancer-specific mortality (P <.001) at 5 years. Conclusions: Elevated NLR in HNSCC confers a poor prognosis.

KW - head and neck squamous cell carcinoma

KW - laryngeal carcinoma

KW - neutrophil-to-lymphocyte ratio

KW - oral cavity carcinoma

KW - oropharyngeal carcinoma

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ER -

Neutrophil-to-lymphocyte ratio as a prognostic indicator for overall and cancer-specific survival in squamous cell carcinoma of the head and neck

Abstract

Keywords

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