Neutrophil Subsets, Platelets, and Vascular Disease in Psoriasis

Heather L. Teague, Nevin J. Varghese, Lam C. Tsoi, Amit K. Dey, Michael S. Garshick, Joanna I. Silverman, Yvonne Baumer, Charlotte L. Harrington, Erin Stempinski, Youssef A. Elnabawi, Pradeep K. Dagur, Kairong Cui, Ilker Tunc, Fayaz Seifuddin, Aditya A. Joshi, Elena Stansky, Monica M. Purmalek, Justin A. Rodante, Andrew Keel, Tarek Z. AridiCarmelo Carmona-Rivera, Gregory E. Sanda, Marcus Y. Chen, Mehdi Pirooznia, J. Philip McCoy, Joel M. Gelfand, Keji Zhao, Johann E. Gudjonsson, Martin P. Playford, Mariana J. Kaplan, Jeffrey S. Berger, Nehal N. Mehta

Research output: Contribution to journalArticlepeer-review

56 Scopus citations

Abstract

Psoriasis is an inflammatory skin disease associated with increased cardiovascular risk and serves as a reliable model to study inflammatory atherogenesis. Because neutrophils are implicated in atherosclerosis development, this study reports that the interaction among low-density granulocytes, a subset of neutrophils, and platelets is associated with a noncalcified coronary plaque burden assessed by coronary computed tomography angiography. Because early atherosclerotic noncalcified burden can lead to fatal myocardial infarction, the low-density granulocyte−platelet interaction may play a crucial target for clinical intervention.

Original languageEnglish
Pages (from-to)1-14
Number of pages14
JournalJACC: Basic to Translational Science
Volume4
Issue number1
DOIs
StatePublished - Feb 2019
Externally publishedYes

Keywords

  • cardiovascular disease
  • low-density granulocytes
  • neutrophils
  • platelets
  • psoriasis

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