TY - JOUR
T1 - Neutralizing anti-influenza virus monoclonal antibodies
T2 - Therapeutics and tools for discovery
AU - Martinez, Osvaldo
AU - Tsibane, Tshidi
AU - Basler, Christopher F.
PY - 2009/2
Y1 - 2009/2
N2 - The human antibody response to influenza virus infection plays a protective role against re-infection, yet little molecular detail is available regarding how human antibodies, when characterized at the monoclonal level, neutralize this important human pathogen. Recent studies, using a diverse array of strategies, have isolated and characterized human anti-virus neutralizing antibodies and shed light not only on the specificity and origin of these antibodies but on their potential for therapeutic use against influenza virus infection.
AB - The human antibody response to influenza virus infection plays a protective role against re-infection, yet little molecular detail is available regarding how human antibodies, when characterized at the monoclonal level, neutralize this important human pathogen. Recent studies, using a diverse array of strategies, have isolated and characterized human anti-virus neutralizing antibodies and shed light not only on the specificity and origin of these antibodies but on their potential for therapeutic use against influenza virus infection.
KW - Antibody
KW - Influenza virus
KW - Memory B cell
KW - Monoclonal
UR - http://www.scopus.com/inward/record.url?scp=60849088256&partnerID=8YFLogxK
U2 - 10.1080/08830180802593540
DO - 10.1080/08830180802593540
M3 - Review article
C2 - 19241254
AN - SCOPUS:60849088256
SN - 0883-0185
VL - 28
SP - 69
EP - 92
JO - International Reviews of Immunology
JF - International Reviews of Immunology
IS - 1-2
ER -