Neutralization of syncytium-inducing primary isolates by sera from human immunodeficiency virus (HlV)-uninfected recipients of candidate HIV vaccines

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Abstract

Most candidate human immunodeficiency virus (HIV)-1 vaccines induce antibodies that neutralize T cell line-adapted HIV-1 strains. Until recently, however, no neutralizing activity against primary HIV-1 isolates had been demonstrated in sera from human vaccinees. Since most candidate HIV-1 vaccines have been constructed from T cell line-adapted syncytium-inducing (SI) strains, experiments were done to test whether sera from recipients of Si-based vaccines could preferentially neutralize SI primary HIV-1 isolates. Various neutralization assays were performed with sera from volunteers receiving AL-VACgp160MN and/or rgp120SF2. Neutralizing activity was detected against 4 of 8 SI primary isolates but against none of 5 non-SI primary isolates. The data suggest that, for the induction of neutralizing antibodies to a broad array of HIV-1 primary isolates, a polyvalent vaccine will be needed containing representatives of more than a single category of viruses.

Original languageEnglish
Pages (from-to)1502-1506
Number of pages5
JournalJournal of Infectious Diseases
Volume178
Issue number5 SUPPL.
DOIs
StatePublished - 1998
Externally publishedYes

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