Neutralization of diverse human immunodeficiency virus type 1 variants by an anti-V3 human monoclonal antibody

Miroslaw K. Gorny, Anthony J. Conley, Sylwia Karwowska, Aby Buchbinder, Jian Yin Xu, Emilio A. Emini, Scott Koenig, Susan Zolla-Pazner

Research output: Contribution to journalArticlepeer-review

303 Scopus citations

Abstract

The third variable region (V3) of the HIV-1 gp120 envelope glycoprotein is thought to induce potent neutralizing antibodies which are generally defined as type specific and reactive with individual viral isolates. In contrast, the CD4-binding domain is thought to induce neutralizing antibodies that are group specific and capable of neutralizing all isolates of HIV-1. However, in this study, we used a panel of human monoclonal antibodies to these regions of gp120 which displays specificities and neutralizing activities that challenge these tenets. In particular, we used a human monoclonal antibody to the V3 domain with exceptionally potent and broad neutralizing activity against many diverse HIV-1 isolates. The anti-CD4-binding domain antibodies, on the other hand, showed a more restricted pattern of activity.

Original languageEnglish
Pages (from-to)7538-7542
Number of pages5
JournalJournal of Virology
Volume66
Issue number12
StatePublished - Dec 1992
Externally publishedYes

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