Neurovascular adaptations modulating cognition, mood, and stress responses

Laurence Dion-Albert, Katarzyna A. Dudek, Scott J. Russo, Matthew Campbell, Caroline Menard

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

The neurovascular unit (NVU) is a dynamic center for substance exchange between the blood and the brain, making it an essential gatekeeper for central nervous system (CNS) homeostasis. Recent evidence supports a role for the NVU in modulating brain function and cognition. In addition, alterations in NVU processes are observed in response to stress, although the mechanisms via which they can affect mood and cognitive functions remain elusive. Here, we summarize recent studies of neurovascular regulation of emotional processes and cognitive function, including under stressful conditions. We also highlight relevant RNA-sequencing (RNA-seq) databases aiming to profile the NVU along with innovative tools to study and manipulate NVU function that can be exploited in the context of cognition and stress research throughout development, aging, or brain disorders.

Original languageEnglish
Pages (from-to)276-292
Number of pages17
JournalTrends in Neurosciences
Volume46
Issue number4
DOIs
StatePublished - Apr 2023

Keywords

  • attention
  • behavioral flexibility
  • blood–brain barrier
  • cognitive flexibility
  • depression
  • memory

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