@article{cc5f68a860ac452992404ea7fc2b83e4,
title = "Neurovascular adaptations modulating cognition, mood, and stress responses",
abstract = "The neurovascular unit (NVU) is a dynamic center for substance exchange between the blood and the brain, making it an essential gatekeeper for central nervous system (CNS) homeostasis. Recent evidence supports a role for the NVU in modulating brain function and cognition. In addition, alterations in NVU processes are observed in response to stress, although the mechanisms via which they can affect mood and cognitive functions remain elusive. Here, we summarize recent studies of neurovascular regulation of emotional processes and cognitive function, including under stressful conditions. We also highlight relevant RNA-sequencing (RNA-seq) databases aiming to profile the NVU along with innovative tools to study and manipulate NVU function that can be exploited in the context of cognition and stress research throughout development, aging, or brain disorders.",
keywords = "attention, behavioral flexibility, blood–brain barrier, cognitive flexibility, depression, memory",
author = "Laurence Dion-Albert and Dudek, {Katarzyna A.} and Russo, {Scott J.} and Matthew Campbell and Caroline Menard",
note = "Funding Information: This work was supported by the Canadian Institutes for Health Research (CIHR) (Project Grant # 427011 to C.M.), Natural Sciences and Engineering Research Council of Canada (Discovery Grant # RGPIN-2019-06499 to C.M.), Fonds de Recherche du Quebec – Sante (FRQS, Junior 2 salary award to C.M.), Brain Canada Foundation (2019 Future Leaders in Canadian Brain Research to C.M.) and Canada First Research Excellence Fund (Sentinel North Research Chair to C.M.). S.J.R. is supported by a National Institutes of Health grant R01MH104559 and R01MH127820, and M.C. by grants from the European Research Council (ERC: Retina-Rhythm), The Irish Research Council (IRC) and a SFI Centres grant, supported in part by a research grant from SFI under grant number 16/RC/3948, and co-funded under the European Regional Development Fund by FutureNeuro industry partners. Scholarships awarded to L.D.A. and K.A.D. are funded by CIHR and FRQS , respectively. Publisher Copyright: {\textcopyright} 2023 The Author(s)",
year = "2023",
month = apr,
doi = "10.1016/j.tins.2023.01.005",
language = "English",
volume = "46",
pages = "276--292",
journal = "Trends in Neurosciences",
issn = "0378-5912",
publisher = "Elsevier Ltd.",
number = "4",
}