TY - JOUR
T1 - Neurotrophin receptors
T2 - Mediators of life and death
AU - Chao, Moses
AU - Casaccia-Bonnefil, Patrizia
AU - Carter, Bruce
AU - Chittka, Alexandra
AU - Kong, Haeyoung
AU - Yoon, Sung Ok
PY - 1998/5
Y1 - 1998/5
N2 - The mechanism of action of NGF has continued to provide a challenging and formidable problem in signal transduction. NGF can bind independently to two different receptors, the trkA tyrosine kinase receptor and the p75 neurotrophin receptor, which are involved in many different signaling events. In addition to promoting cell differentiation survival, NGF can paradoxically be an inducer of cell death. Several receptor mediated mechanisms are proposed to explain how NGF might act as a trophic factor and as a cell killer. The survival and cell death properties of the receptors are dependent upon the relative ratio of receptors and the persistent nature of the signaling events.
AB - The mechanism of action of NGF has continued to provide a challenging and formidable problem in signal transduction. NGF can bind independently to two different receptors, the trkA tyrosine kinase receptor and the p75 neurotrophin receptor, which are involved in many different signaling events. In addition to promoting cell differentiation survival, NGF can paradoxically be an inducer of cell death. Several receptor mediated mechanisms are proposed to explain how NGF might act as a trophic factor and as a cell killer. The survival and cell death properties of the receptors are dependent upon the relative ratio of receptors and the persistent nature of the signaling events.
KW - Death
KW - NGF
KW - Neurotrophic
KW - Receptor
KW - Signal transduction
UR - http://www.scopus.com/inward/record.url?scp=0032079107&partnerID=8YFLogxK
U2 - 10.1016/S0165-0173(97)00036-2
DO - 10.1016/S0165-0173(97)00036-2
M3 - Article
C2 - 9651545
AN - SCOPUS:0032079107
SN - 0165-0173
VL - 26
SP - 295
EP - 301
JO - Brain Research Reviews
JF - Brain Research Reviews
IS - 2-3
ER -