Neurotrophic Mechanisms in Drug Addiction

Carlos A. Bolaños; Eric J. Nestler

doi:10.1385/nmm:5:1:069

Neurotrophic Mechanisms in Drug Addiction

Carlos A. Bolaños, Eric J. Nestler

Research output: Contribution to journal › Review article › peer-review

159 Scopus citations

Abstract

The involvement of neurotrophic factors in neuronal survival and differentiation is well established. The more recent realization that these factors also play pivotal roles in the maintenance and activity-dependent remodeling of neuronal functioning in the adult brain has generated excitement in the neurosciences. Neurotrophic factors have been implicated in the modulation of synaptic transmission and in the mechanisms underlying learning and memory, mood disorders, and drug addiction. Here the evidence for the role of neurotrophins and other neurotrophic factors-and the signaling pathways they activate-in mediating long-term molecular, cellular, and behavioral adaptations associated with drug addiction is reviewed.

Original language	English
Pages (from-to)	69-83
Number of pages	15
Journal	NeuroMolecular Medicine
Volume	5
Issue number	1
DOIs	https://doi.org/10.1385/nmm:5:1:069
State	Published - 2004
Externally published	Yes

Keywords

Brain-derived neurotrophic factor (BDNF)
Cocaine, morphine
Nucleus accumbens
Trk receptor
Ventral tegmental area

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10.1385/nmm:5:1:069

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title = "Neurotrophic Mechanisms in Drug Addiction",

abstract = "The involvement of neurotrophic factors in neuronal survival and differentiation is well established. The more recent realization that these factors also play pivotal roles in the maintenance and activity-dependent remodeling of neuronal functioning in the adult brain has generated excitement in the neurosciences. Neurotrophic factors have been implicated in the modulation of synaptic transmission and in the mechanisms underlying learning and memory, mood disorders, and drug addiction. Here the evidence for the role of neurotrophins and other neurotrophic factors-and the signaling pathways they activate-in mediating long-term molecular, cellular, and behavioral adaptations associated with drug addiction is reviewed.",

keywords = "Brain-derived neurotrophic factor (BDNF), Cocaine, morphine, Nucleus accumbens, Trk receptor, Ventral tegmental area",

author = "Bola{\~n}os, {Carlos A.} and Nestler, {Eric J.}",

note = "Funding Information: Preparation of this review was supported by grants from the National Institute on Drug Abuse. The authors thank Nick Sanchez for his help with the figures.",

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T1 - Neurotrophic Mechanisms in Drug Addiction

AU - Bolaños, Carlos A.

AU - Nestler, Eric J.

N1 - Funding Information: Preparation of this review was supported by grants from the National Institute on Drug Abuse. The authors thank Nick Sanchez for his help with the figures.

PY - 2004

Y1 - 2004

N2 - The involvement of neurotrophic factors in neuronal survival and differentiation is well established. The more recent realization that these factors also play pivotal roles in the maintenance and activity-dependent remodeling of neuronal functioning in the adult brain has generated excitement in the neurosciences. Neurotrophic factors have been implicated in the modulation of synaptic transmission and in the mechanisms underlying learning and memory, mood disorders, and drug addiction. Here the evidence for the role of neurotrophins and other neurotrophic factors-and the signaling pathways they activate-in mediating long-term molecular, cellular, and behavioral adaptations associated with drug addiction is reviewed.

AB - The involvement of neurotrophic factors in neuronal survival and differentiation is well established. The more recent realization that these factors also play pivotal roles in the maintenance and activity-dependent remodeling of neuronal functioning in the adult brain has generated excitement in the neurosciences. Neurotrophic factors have been implicated in the modulation of synaptic transmission and in the mechanisms underlying learning and memory, mood disorders, and drug addiction. Here the evidence for the role of neurotrophins and other neurotrophic factors-and the signaling pathways they activate-in mediating long-term molecular, cellular, and behavioral adaptations associated with drug addiction is reviewed.

KW - Brain-derived neurotrophic factor (BDNF)

KW - Cocaine, morphine

KW - Nucleus accumbens

KW - Trk receptor

KW - Ventral tegmental area

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M3 - Review article

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VL - 5

SP - 69

EP - 83

JO - NeuroMolecular Medicine

JF - NeuroMolecular Medicine

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Neurotrophic Mechanisms in Drug Addiction

Abstract

Keywords

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