Neurotripanosomiasis americana: aspectos clínicos de un problema básico.

Translated title of the contribution: Neurological effects of American trypanosomyiasis: clinical aspects

Fidias E. León-Sarmiento, Diddier G. Prada, Jaime Bayona-Prieto, Vladimir Valderrama, Ingrid García, Marta E. León, Dan Sunnemark

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

Trypanosoma cruzi, causative agent of Chagas disease, affects not only cardiac and intestinal structures but also neurological structures. A high prevalence of T. cruzi infection occurs in Colombia, prompting the present study. First, a qualitative metaanalysis was undertaken using the PubMed database, the electronic internet engine Altavista, Colombian journals indexed by Colciencias, and three relevant textbooks. The following key words were used: Trypanosoma, Chagas disease, nervous system, spinal cord, central nervous system, peripheral nervous system, neuromuscular junction, autonomic nervous system, muscle, muscle disorders, neuromuscular disease, neuromuscular disorders, synapticopathies and dysautonomia. The documents analyzed numbered 116 and included original papers, reviews, case reports, editorials, brief communications, conferences and book chapters. At minimum, each document included data involving ELISA testing, indirect immunofluorescense, or parasitemia levels in the clinical, serological or histopathological studies. Polymerase chain reaction (PCR) studies were not included because of the recent introduction of PCR as a confirmatory technique for Chagas disease in Colombia. Chagas disease affects the central, the peripheral and the autonomic nervous system in humans, although its effects on the antonomic system is most commonly investigated in Colombia. Neurological lesions must be evaluated carefully, because patients may be misdiagnosed and treated as carriers of 'idiopathic' diseases. Neurological pathologies poses a serious threat in Colombia due to the prevalence of Chagas disease.

Translated title of the contributionNeurological effects of American trypanosomyiasis: clinical aspects
Original languageSpanish
Pages (from-to)462-475
Number of pages14
JournalBiomedica
Volume23
Issue number4
DOIs
StatePublished - Dec 2003
Externally publishedYes

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