Neurotransmitter metabolites in the cerebrospinal fluid of man following physostigmine

Kenneth L. Davis; Leo E. Hollister; Frederick K. Goodwin; Edna K. Gordon

doi:10.1016/0024-3205(77)90258-2

Neurotransmitter metabolites in the cerebrospinal fluid of man following physostigmine

Kenneth L. Davis, Leo E. Hollister, Frederick K. Goodwin, Edna K. Gordon

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

A 3.0 mg dose of physostigmine or normal saline was given intravenously to 23 normal subjects who had been treated with probenecid. Homovanillic acid and 3-methoxy-4-hydroxyphenylglycol concentrations were significantly higher in the lumbar cerebrospinal fluid of subjects who received physostigmine than subjects who received normal saline. This establishes biochemical evidence for a cholinergic link in the central nervous system of man.

Original language	English
Pages (from-to)	933-936
Number of pages	4
Journal	Life Sciences
Volume	21
Issue number	7
DOIs	https://doi.org/10.1016/0024-3205(77)90258-2
State	Published - 1 Oct 1977
Externally published	Yes

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title = "Neurotransmitter metabolites in the cerebrospinal fluid of man following physostigmine",

abstract = "A 3.0 mg dose of physostigmine or normal saline was given intravenously to 23 normal subjects who had been treated with probenecid. Homovanillic acid and 3-methoxy-4-hydroxyphenylglycol concentrations were significantly higher in the lumbar cerebrospinal fluid of subjects who received physostigmine than subjects who received normal saline. This establishes biochemical evidence for a cholinergic link in the central nervous system of man.",

author = "Davis, {Kenneth L.} and Hollister, {Leo E.} and Goodwin, {Frederick K.} and Gordon, {Edna K.}",

note = "Funding Information: Supported in part by grant MH-03030, National Institute of Mental Health and Research Service, Veterans administration, Palo Alto, California 94304.",

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T1 - Neurotransmitter metabolites in the cerebrospinal fluid of man following physostigmine

AU - Davis, Kenneth L.

AU - Hollister, Leo E.

AU - Goodwin, Frederick K.

AU - Gordon, Edna K.

N1 - Funding Information: Supported in part by grant MH-03030, National Institute of Mental Health and Research Service, Veterans administration, Palo Alto, California 94304.

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Y1 - 1977/10/1

N2 - A 3.0 mg dose of physostigmine or normal saline was given intravenously to 23 normal subjects who had been treated with probenecid. Homovanillic acid and 3-methoxy-4-hydroxyphenylglycol concentrations were significantly higher in the lumbar cerebrospinal fluid of subjects who received physostigmine than subjects who received normal saline. This establishes biochemical evidence for a cholinergic link in the central nervous system of man.

AB - A 3.0 mg dose of physostigmine or normal saline was given intravenously to 23 normal subjects who had been treated with probenecid. Homovanillic acid and 3-methoxy-4-hydroxyphenylglycol concentrations were significantly higher in the lumbar cerebrospinal fluid of subjects who received physostigmine than subjects who received normal saline. This establishes biochemical evidence for a cholinergic link in the central nervous system of man.

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Neurotransmitter metabolites in the cerebrospinal fluid of man following physostigmine

Abstract

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