Neurotransmitter dysfunction in patients with borderline personality disorder

Irene G. Gurvits, Harold W. Koenigsberg, Larry J. Siever

Research output: Contribution to journalArticlepeer-review

91 Scopus citations

Abstract

Neurotransmitter system dysfunction may contribute to the borderline personality disorder traits of impulsive aggression and affective instability. This article reviews evidence from neurochemical assays, receptor-density studies, neuroendocrine challenge paradigms, functional neuroimaging studies, and candidate-gene research, which converge to identify particular neurotransmitter systems that seem to be dysregulated in patients with borderline personality disorder.

Original languageEnglish
Pages (from-to)27-40
Number of pages14
JournalPsychiatric Clinics of North America
Volume23
Issue number1
DOIs
StatePublished - 2000

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