Neurotransmitter Deficits in Alzheimer's Disease: Criteria for Significance

BLAINE S. GREENWALD, RICHARD C. MOHS, KENNETH L. DAVIS

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

A series of histopathologic, morphologic, and pharmacologic criteria are proposed to establish the significance of neurochemical deficits in Alzheimer's disease. The underlying pathogenic biochemistry of a better understood neurotransmitter‐deficiency syndrome, Parkinson's disease, validates these criteria. The major neurotransmitter systems are evaluated against these guidelines. Only the cholinergic system fulfills all the criteria. Noradrenergic mechanisms are also implicated. Subsequent neurochemical abnormalities found in the brains of patients with Alzheimer's disease can be evaluated against these criteria. 1983 The American Geriatrics Society

Original languageEnglish
Pages (from-to)310-316
Number of pages7
JournalJournal of the American Geriatrics Society
Volume31
Issue number5
DOIs
StatePublished - May 1983
Externally publishedYes

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