TY - JOUR
T1 - Neurotransmitter Deficits in Alzheimer's Disease
T2 - Criteria for Significance
AU - GREENWALD, BLAINE S.
AU - MOHS, RICHARD C.
AU - DAVIS, KENNETH L.
PY - 1983/5
Y1 - 1983/5
N2 - A series of histopathologic, morphologic, and pharmacologic criteria are proposed to establish the significance of neurochemical deficits in Alzheimer's disease. The underlying pathogenic biochemistry of a better understood neurotransmitter‐deficiency syndrome, Parkinson's disease, validates these criteria. The major neurotransmitter systems are evaluated against these guidelines. Only the cholinergic system fulfills all the criteria. Noradrenergic mechanisms are also implicated. Subsequent neurochemical abnormalities found in the brains of patients with Alzheimer's disease can be evaluated against these criteria. 1983 The American Geriatrics Society
AB - A series of histopathologic, morphologic, and pharmacologic criteria are proposed to establish the significance of neurochemical deficits in Alzheimer's disease. The underlying pathogenic biochemistry of a better understood neurotransmitter‐deficiency syndrome, Parkinson's disease, validates these criteria. The major neurotransmitter systems are evaluated against these guidelines. Only the cholinergic system fulfills all the criteria. Noradrenergic mechanisms are also implicated. Subsequent neurochemical abnormalities found in the brains of patients with Alzheimer's disease can be evaluated against these criteria. 1983 The American Geriatrics Society
UR - http://www.scopus.com/inward/record.url?scp=0020604050&partnerID=8YFLogxK
U2 - 10.1111/j.1532-5415.1983.tb04877.x
DO - 10.1111/j.1532-5415.1983.tb04877.x
M3 - Article
C2 - 6132940
AN - SCOPUS:0020604050
SN - 0002-8614
VL - 31
SP - 310
EP - 316
JO - Journal of the American Geriatrics Society
JF - Journal of the American Geriatrics Society
IS - 5
ER -