Neurotoxic Reactive Astrocytes Drive Neuronal Death after Retinal Injury

Kevin A. Guttenplan; Benjamin K. Stafford; Rana N. El-Danaf; Drew I. Adler; Alexandra E. Münch; Maya K. Weigel; Andrew D. Huberman; Shane A. Liddelow

doi:10.1016/j.celrep.2020.107776

Neurotoxic Reactive Astrocytes Drive Neuronal Death after Retinal Injury

Kevin A. Guttenplan, Benjamin K. Stafford, Rana N. El-Danaf, Drew I. Adler, Alexandra E. Münch, Maya K. Weigel, Andrew D. Huberman, Shane A. Liddelow

Research output: Contribution to journal › Article › peer-review

141 Scopus citations

Abstract

Guttenplan et al. show that dampening the formation of reactive astrocytes prevents neuronal death following acute optic nerve crush or in a chronic model of glaucoma, with spared neurons remaining electrophysiologically functional. More generally, they show that injury is required to induce neurons to become susceptible to astrocyte-mediated toxicity.

Original language	English
Article number	107776
Journal	Cell Reports
Volume	31
Issue number	12
DOIs	https://doi.org/10.1016/j.celrep.2020.107776
State	Published - 23 Jun 2020
Externally published	Yes

Keywords

astrocytes
astrogliosis
glaucoma
glia
neurodegeneration
neuroprotection
optic nerve crush
reactive astrocyte

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10.1016/j.celrep.2020.107776

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title = "Neurotoxic Reactive Astrocytes Drive Neuronal Death after Retinal Injury",

abstract = "Guttenplan et al. show that dampening the formation of reactive astrocytes prevents neuronal death following acute optic nerve crush or in a chronic model of glaucoma, with spared neurons remaining electrophysiologically functional. More generally, they show that injury is required to induce neurons to become susceptible to astrocyte-mediated toxicity.",

keywords = "astrocytes, astrogliosis, glaucoma, glia, neurodegeneration, neuroprotection, optic nerve crush, reactive astrocyte",

author = "Guttenplan, {Kevin A.} and Stafford, {Benjamin K.} and El-Danaf, {Rana N.} and Adler, {Drew I.} and M{\"u}nch, {Alexandra E.} and Weigel, {Maya K.} and Huberman, {Andrew D.} and Liddelow, {Shane A.}",

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AU - Münch, Alexandra E.

AU - Weigel, Maya K.

AU - Huberman, Andrew D.

AU - Liddelow, Shane A.

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KW - astrogliosis

KW - glaucoma

KW - glia

KW - neurodegeneration

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Neurotoxic Reactive Astrocytes Drive Neuronal Death after Retinal Injury

Abstract

Keywords

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