TY - JOUR
T1 - Neuropsychological functioning in youth with bipolar disorder
AU - Doyle, Alysa E.
AU - Wilens, Timothy E.
AU - Kwon, Anne
AU - Seidman, Larry J.
AU - Faraone, Stephen V.
AU - Fried, Ronna
AU - Swezey, Allison
AU - Snyder, Lindsey
AU - Biederman, Joseph
N1 - Funding Information:
This work was supported in part by National Institute of Mental Health (NIMH) Grant No. K08-MH-66072 to Dr. Doyle and National Institute on Drug Abuse Grant No. RO1 DA12945 to Dr. Wilens. Aspects of this work were presented on April 3, 2004, at the NIMH Pediatric Bipolar Conference in Boston, Massachusetts.
PY - 2005/10/1
Y1 - 2005/10/1
N2 - Background: Little is known about the neuropsychological status of youth with bipolar disorder (BPD) or whether cognitive deficits in this population are accounted for by comorbidity with attention deficit/hyperactivity disorder (ADHD). We compared neuropsychological and academic functioning of youth with and without DSM-IV BPD, controlling for effects of comorbid ADHD. Methods: Fifty-seven youth with BPD and 46 healthy control subjects were assessed on a battery of clinical neuropsychological measures including subtests from the Wechsler Intelligence Scales for Children and Adults (Third Editions), the Stroop, the Wisconsin Card Sorting Test, the Rey-Osterreith Complex Figure, an auditory working memory Continuous Performance Test, a measure of verbal learning, and the Wide Range Achievement Test-Third Edition. Results: Bipolar disorder was associated with impairments on subtests reflecting sustained attention, working memory, and processing speed after controlling for ADHD. Additionally, decrements of moderate effect sizes were found for measures of interference control, abstract problem solving, and verbal learning but did not meet criteria for statistical significance. Conclusions: After controlling for ADHD, youth with BPD show neuropsychological deficits similar to impairments found in adults with the disorder. Further studies are needed to understand the clinical implications of these impairments as well as their role in the underlying risk for pediatric BPD.
AB - Background: Little is known about the neuropsychological status of youth with bipolar disorder (BPD) or whether cognitive deficits in this population are accounted for by comorbidity with attention deficit/hyperactivity disorder (ADHD). We compared neuropsychological and academic functioning of youth with and without DSM-IV BPD, controlling for effects of comorbid ADHD. Methods: Fifty-seven youth with BPD and 46 healthy control subjects were assessed on a battery of clinical neuropsychological measures including subtests from the Wechsler Intelligence Scales for Children and Adults (Third Editions), the Stroop, the Wisconsin Card Sorting Test, the Rey-Osterreith Complex Figure, an auditory working memory Continuous Performance Test, a measure of verbal learning, and the Wide Range Achievement Test-Third Edition. Results: Bipolar disorder was associated with impairments on subtests reflecting sustained attention, working memory, and processing speed after controlling for ADHD. Additionally, decrements of moderate effect sizes were found for measures of interference control, abstract problem solving, and verbal learning but did not meet criteria for statistical significance. Conclusions: After controlling for ADHD, youth with BPD show neuropsychological deficits similar to impairments found in adults with the disorder. Further studies are needed to understand the clinical implications of these impairments as well as their role in the underlying risk for pediatric BPD.
KW - Juvenile mania
KW - Neuropsychology
KW - Pediatric bipolar disorder
UR - http://www.scopus.com/inward/record.url?scp=26844438577&partnerID=8YFLogxK
U2 - 10.1016/j.biopsych.2005.07.019
DO - 10.1016/j.biopsych.2005.07.019
M3 - Article
C2 - 16199011
AN - SCOPUS:26844438577
SN - 0006-3223
VL - 58
SP - 540
EP - 548
JO - Biological Psychiatry
JF - Biological Psychiatry
IS - 7
ER -