Neuroprotective action of resveratrol

Stéphane Bastianetto, Caroline Ménard, Rémi Quirion

Research output: Contribution to journalReview articlepeer-review

254 Scopus citations

Abstract

Low-to-moderate red wine consumption appeared to reduce age-related neurological disorders including macular degeneration, stroke, and cognitive deficits with or without dementia. Resveratrol has been considered as one of the key ingredients responsible for the preventive action of red wine since the stilbene displays a neuroprotective action in various models of toxicity. Besides its well documented free radical scavenging and anti-inflammatory properties, resveratrol has been shown to increase the clearance of beta-amyloid, a key feature of Alzheimer's disease, and to modulate intracellular effectors associated with oxidative stress (e.g. heme oxygenase), neuronal energy homeostasis (e.g. AMP kinase), program cell death (i.e. AIF) and longevity (i.e. sirtuins). This article summarizes the most recent findings on mechanisms of action involved in the protective effects of this multi target polyphenol, and discusses its possible roles in the prevention of various age-related neurological disorders. This article is part of a Special Issue entitled: Resveratrol: Challenges in translating pre-clinical findings to improved patient outcomes.

Original languageEnglish
Pages (from-to)1195-1201
Number of pages7
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Volume1852
Issue number6
DOIs
StatePublished - 1 Jun 2015
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Amyloid
  • Ischemia
  • Kinase
  • Polyphenol
  • SIRT-1

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