Neuropeptide Y improves cisplatin-induced bone marrow dysfunction without blocking chemotherapeutic efficacy in a cancer mouse model

Min Hee Park, In Kyung Jung, Woo Kie Min, Jin Ho Choi, Gyu Man Kim, Hee Kyung Jin, Jae Sung Bae

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Cisplatin is the most effective and widely used chemotherapeutic agent for many types of cancer. Unfortunately, its clinical use is limited by its adverse effects, notably bone marrow suppression leading to abnormal hematopoiesis. We previously revealed that neuropeptide Y (NPY) is responsible for the maintenance of hematopoietic stem cell (HSC) function by protecting the sympathetic nervous system (SNS) fibers survival from chemotherapy-induced bone marrow impairment. Here, we show the NPY-mediated protective effect against bone marrow dysfunction due to cisplatin in an ovarian cancer mouse model. During chemotherapy, NPY mitigates reduction in HSC abundance and destruction of SNS fibers in the bone marrow without blocking the anticancer efficacy of cisplatin, and it results in the restoration of blood cells and amelioration of sensory neuropathy. Therefore, these results suggest that NPY can be used as a potentially effective agent to improve bone marrow dysfunction during cisplatinbased cancer therapy.

Original languageEnglish
Pages (from-to)417-422
Number of pages6
JournalBMB Reports
Volume50
Issue number8
DOIs
StatePublished - 2017
Externally publishedYes

Keywords

  • Bone marrow dysfunction
  • Cancer
  • Chemotherapy-induced side effects
  • Hematopoietic stem cell
  • Neuropeptide Y

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