Neuropathic Pain Syndromes in Neuroborreliosis

Houman Danesh, Elina Zakin

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations


Lyme neuroborreliosis is a neurologic condition after infection with Borrelia burgodrferi. It can affect many organ systems, and 10%–15% of individuals develop Lyme disease. Lyme disease can cause lymphocytic meningitis, cranial neuropathies, radiculoneuritis, post Lyme disease syndrome, and chronic Lyme disease. The pathophysiology, neurologic manifestations of Lyme disease, and post Lyme disease syndrome are reviewed. An overview of antimicrobial therapy and treatment of post Lyme disease syndrome is followed by pain in neuroborreliosis and treatment options, which include serotonin-norepinephrine reuptake inhibitors, calcium channel ligands, and opioid analgesics and tramadol. This is followed by nonpharmacologic therapy for neuropathic pain.

Original languageEnglish
Title of host publicationChallenging Neuropathic Pain Syndromes
Subtitle of host publicationEvaluation and Evidence-Based Treatment
Number of pages7
ISBN (Electronic)9780323485661
ISBN (Print)9780323496070
StatePublished - 1 Jan 2017


  • Borrelia burgdorferi
  • Calcium channel ligands
  • Lyme disease
  • Pain
  • Post Lyme disease syndrome
  • Serotonin-norepinephrine reuptake inhibitors
  • Treatment


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