Neuronal antinuclear antibody in sensory neuronopathy from lung cancer

Francesc Graus; Carlos Cordon-Cardo; Jerome B. Posner

doi:10.1212/wnl.35.4.538

Neuronal antinuclear antibody in sensory neuronopathy from lung cancer

Francesc Graus
, Carlos Cordon-Cardo
, Jerome B. Posner

Research output: Contribution to journal › Article › peer-review

394 Scopus citations

Abstract

We found an antinuclear antibody highly restricted to nuclei of neurons in two patients with subacute sensory neuronopathy complicating oat cell carcinoma of the lung. Serum was tested by indirect immunofluorescence and immunoperoxidase staining. At low concentrations of antibody, only the nuclei of the neurons were stained. At high concentrations, there was also staining of the nuclei of glial cells and fetal nonneural tissues. The cytoplasm of most neurons was stained with the immunoperoxidase method.

Original language	English
Pages (from-to)	538-543
Number of pages	6
Journal	Neurology
Volume	35
Issue number	4
DOIs	https://doi.org/10.1212/wnl.35.4.538
State	Published - Apr 1985
Externally published	Yes

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title = "Neuronal antinuclear antibody in sensory neuronopathy from lung cancer",

abstract = "We found an antinuclear antibody highly restricted to nuclei of neurons in two patients with subacute sensory neuronopathy complicating oat cell carcinoma of the lung. Serum was tested by indirect immunofluorescence and immunoperoxidase staining. At low concentrations of antibody, only the nuclei of the neurons were stained. At high concentrations, there was also staining of the nuclei of glial cells and fetal nonneural tissues. The cytoplasm of most neurons was stained with the immunoperoxidase method.",

author = "Francesc Graus and Carlos Cordon-Cardo and Posner, \{Jerome B.\}",

year = "1985",

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AU - Cordon-Cardo, Carlos

AU - Posner, Jerome B.

PY - 1985/4

Y1 - 1985/4

N2 - We found an antinuclear antibody highly restricted to nuclei of neurons in two patients with subacute sensory neuronopathy complicating oat cell carcinoma of the lung. Serum was tested by indirect immunofluorescence and immunoperoxidase staining. At low concentrations of antibody, only the nuclei of the neurons were stained. At high concentrations, there was also staining of the nuclei of glial cells and fetal nonneural tissues. The cytoplasm of most neurons was stained with the immunoperoxidase method.

AB - We found an antinuclear antibody highly restricted to nuclei of neurons in two patients with subacute sensory neuronopathy complicating oat cell carcinoma of the lung. Serum was tested by indirect immunofluorescence and immunoperoxidase staining. At low concentrations of antibody, only the nuclei of the neurons were stained. At high concentrations, there was also staining of the nuclei of glial cells and fetal nonneural tissues. The cytoplasm of most neurons was stained with the immunoperoxidase method.

UR - https://www.scopus.com/pages/publications/0021797212

U2 - 10.1212/wnl.35.4.538

DO - 10.1212/wnl.35.4.538

M3 - Article

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AN - SCOPUS:0021797212

SN - 0028-3878

VL - 35

SP - 538

EP - 543

JO - Neurology

JF - Neurology

IS - 4

ER -

Neuronal antinuclear antibody in sensory neuronopathy from lung cancer

Abstract

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