Neuron specific enolase (NSE) and thymidine kinase (TK) as markers in biological fluids of brain tumor patients

A. Boiardi; L. Munari; A. Silvani; C. L. Solero; E. Bombardieri

doi:10.1007/BF02335938

Neuron specific enolase (NSE) and thymidine kinase (TK) as markers in biological fluids of brain tumor patients

A. Boiardi, L. Munari, A. Silvani, C. L. Solero, E. Bombardieri

Research output: Contribution to journal › Article › peer-review

Abstract

We studied the activity of two enzymes NSE and TK in the biological fluids of 104 patients with nervous system diseases, who fell into 4 groups. 20 subjects out of 35 in the tumor group had glial tumors. We fixed a cut-off value of NSE and TK activity at the 95^th percentile of the control group, both in serum and in CSF. The aim of our investigation was to assess the reliability of TK and NSE assays in separating brain tumors from other neurological diseases. In our patients, most of the TK activity above the cut-off value was found in the tumor group. Serum TK seems to be a useful marker for following up cerebral tumors after surgery, but NSE is less useful for this purpose.

Original language	English
Pages (from-to)	359-366
Number of pages	8
Journal	Neurological Sciences
Volume	11
Issue number	4
DOIs	https://doi.org/10.1007/BF02335938
State	Published - Aug 1990
Externally published	Yes

Keywords

Thymidine kinase
brain tumor
markers
neuron specific enolase

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10.1007/BF02335938

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title = "Neuron specific enolase (NSE) and thymidine kinase (TK) as markers in biological fluids of brain tumor patients",

abstract = "We studied the activity of two enzymes NSE and TK in the biological fluids of 104 patients with nervous system diseases, who fell into 4 groups. 20 subjects out of 35 in the tumor group had glial tumors. We fixed a cut-off value of NSE and TK activity at the 95th percentile of the control group, both in serum and in CSF. The aim of our investigation was to assess the reliability of TK and NSE assays in separating brain tumors from other neurological diseases. In our patients, most of the TK activity above the cut-off value was found in the tumor group. Serum TK seems to be a useful marker for following up cerebral tumors after surgery, but NSE is less useful for this purpose.",

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author = "A. Boiardi and L. Munari and A. Silvani and Solero, {C. L.} and E. Bombardieri",

year = "1990",

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T1 - Neuron specific enolase (NSE) and thymidine kinase (TK) as markers in biological fluids of brain tumor patients

AU - Boiardi, A.

AU - Munari, L.

AU - Silvani, A.

AU - Solero, C. L.

AU - Bombardieri, E.

PY - 1990/8

Y1 - 1990/8

N2 - We studied the activity of two enzymes NSE and TK in the biological fluids of 104 patients with nervous system diseases, who fell into 4 groups. 20 subjects out of 35 in the tumor group had glial tumors. We fixed a cut-off value of NSE and TK activity at the 95th percentile of the control group, both in serum and in CSF. The aim of our investigation was to assess the reliability of TK and NSE assays in separating brain tumors from other neurological diseases. In our patients, most of the TK activity above the cut-off value was found in the tumor group. Serum TK seems to be a useful marker for following up cerebral tumors after surgery, but NSE is less useful for this purpose.

AB - We studied the activity of two enzymes NSE and TK in the biological fluids of 104 patients with nervous system diseases, who fell into 4 groups. 20 subjects out of 35 in the tumor group had glial tumors. We fixed a cut-off value of NSE and TK activity at the 95th percentile of the control group, both in serum and in CSF. The aim of our investigation was to assess the reliability of TK and NSE assays in separating brain tumors from other neurological diseases. In our patients, most of the TK activity above the cut-off value was found in the tumor group. Serum TK seems to be a useful marker for following up cerebral tumors after surgery, but NSE is less useful for this purpose.

KW - Thymidine kinase

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KW - markers

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Neuron specific enolase (NSE) and thymidine kinase (TK) as markers in biological fluids of brain tumor patients

Abstract

Keywords

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